盐酸托哌酮
盐酸托哌酮结构式
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常用名 | 盐酸托哌酮 | 英文名 | Tolperisone hydrochloride |
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| CAS号 | 3644-61-9 | 分子量 | 281.821 | |
| 密度 | N/A | 沸点 | 373.9ºC at 760 mmHg | |
| 分子式 | C16H24ClNO | 熔点 | 181-183°C | |
| MSDS | 中文版 美版 | 闪点 | 134.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.
J. Pharmacol. Exp. Ther. 315 , 1237-1246, (2005) The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was investigated. Tolperisone (50-400 microM), eperisone, lanperisone, inaperisone, and silperisone (25-200 microM) dose dependently d... |
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A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.
Eur. J. Pharmacol. 538 , 5-14, (2006) The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain conditions, with the Na(v1.2), Na(v1.3), Na(v1.4), Na(v1.5), Na(v1.6), Na(v1.7), and Na(v1.8) isoforms of voltage dependent sodium channel... |
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Tolperisone--a novel modulator of ionic currents in myelinated axons.
Gen. Physiol. Biophys. 20(4) , 413-29, (2001) The actions of tolperisone on single intact Ranvier nodes of the toad Xenopus were investigated by means of the Hodgkin-Huxley formalism. Adding tolperisone to the bathing medium (100 micromol/l) caused the following fully reversible effects: 1. The sodium pe... |