Tolperisone hydrochloride
Tolperisone hydrochloride structure
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Common Name | Tolperisone hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 3644-61-9 | Molecular Weight | 281.821 | |
| Density | N/A | Boiling Point | 373.9ºC at 760 mmHg | |
| Molecular Formula | C16H24ClNO | Melting Point | 181-183°C | |
| MSDS | Chinese USA | Flash Point | 134.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.
J. Pharmacol. Exp. Ther. 315 , 1237-1246, (2005) The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was investigated. Tolperisone (50-400 microM), eperisone, lanperisone, inaperisone, and silperisone (25-200 microM) dose dependently d... |
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A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.
Eur. J. Pharmacol. 538 , 5-14, (2006) The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain conditions, with the Na(v1.2), Na(v1.3), Na(v1.4), Na(v1.5), Na(v1.6), Na(v1.7), and Na(v1.8) isoforms of voltage dependent sodium channel... |
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Tolperisone--a novel modulator of ionic currents in myelinated axons.
Gen. Physiol. Biophys. 20(4) , 413-29, (2001) The actions of tolperisone on single intact Ranvier nodes of the toad Xenopus were investigated by means of the Hodgkin-Huxley formalism. Adding tolperisone to the bathing medium (100 micromol/l) caused the following fully reversible effects: 1. The sodium pe... |