盐酸乙胺丁醇
盐酸乙胺丁醇结构式
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常用名 | 盐酸乙胺丁醇 | 英文名 | Ethambutol dihydrochloride |
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| CAS号 | 1070-11-7 | 分子量 | 277.232 | |
| 密度 | N/A | 沸点 | 345.3ºC at 760 mmHg | |
| 分子式 | C10H26Cl2N2O2 | 熔点 | 198-200°C | |
| MSDS | 中文版 美版 | 闪点 | 113.7ºC | |
| 符号 |
GHS08 |
信号词 | Danger |
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 102 , 9-16, (2014) A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods w... |
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Transport properties in aqueous ethambutol dihydrochloride.
Int. J. Pharm. 479(2) , 306-11, (2015) Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15K. From these experimental results and by using the appropriate models (Stokes-Eins... |
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Detection of residual rifampicin in urine via fluorescence quenching of gold nanoclusters on paper.
J. Nanobiotechnology 13 , 46, (2015) Rifampicin or rifampin (R) is a common drug used to treat inactive meningitis, cholestatic pruritus and tuberculosis (TB), and it is generally prescribed for long-term administration under regulated dosages. Constant monitoring of rifampicin is important for ... |
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Inhibition of cytochrome P450 by ethambutol in human liver microsomes.
Toxicol. Lett. 229(1) , 33-40, (2014) Although cytochrome P450 inhibition is the major drug-drug interaction (DDI) mechanism in clinical pharmacotherapy, DDI of a number of well-established drugs have not been investigated. Rifampicin, isoniazid, pyrazinamide and ethambutol combination therapy in... |
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Estimation of content of anti-TB drugs supplied at centres of the Revised National TB Control Programme in Tamil Nadu, India.
Trop. Med. Int. Health 18(9) , 1141-4, (2013) To determine the content of certain antituberculosis (TB) drugs supplied at TB treatment centres of the Revised National TB Control Programme (RNTCP) in the state of Tamil Nadu, India.Eight districts across the state were selected, and the following drugs wer... |
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Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study.
JAMA Dermatol. 149(9) , 1040-9, (2013) Sarcoidosis is a chronic granulomatous disease for which there are limited therapeutic options. This is the first randomized, placebo-controlled study to demonstrate that antimycobacterial therapy reduces lesion diameter and disease severity among patients wi... |
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Rapid molecular screening for multidrug-resistant tuberculosis in a resource-limited region of China.
Trop. Med. Int. Health 19(10) , 1259-66, (2014) To investigate the molecular characteristics of MDR and XDR strains circulating in Chongqing, China.The drug target genes conferring for rifampicin (RIF), isoniazid (INH), ethambutol (EMB), ofloxacin (OFLX) and kanamycin (KAN) resistance were screened by DNA ... |
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inh... |
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In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.
Antimicrob. Agents Chemother. 59 , 5664-74, (2015) There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordinary differ... |
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In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis.
Lett. Appl. Microbiol. 58(4) , 344-9, (2014) Previous studies have shown that isoimperatorin (IO), a furanocoumarin isolated from several medicinal plants, has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294). This study demonstrated that IO has antimycobacterial a... |