盐酸乙胺丁醇

• 常用名: 盐酸乙胺丁醇
• 英文名: Ethambutol dihydrochloride
• CAS号: 1070-11-7
• 分子量: 277.232
• 密度: N/A
• 沸点: 345.3ºC at 760 mmHg
• 分子式: C₁₀H₂₆Cl₂N₂O₂
• 熔点: 198-200°C
• 闪点: 113.7ºC

盐酸乙胺丁醇用途

Ethambutol Dihydrochloride is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.Target: AntibacterialEthambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants [1]. Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro [2]. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) [3].

盐酸乙胺丁醇名称

• 中文名: 2,2'-(1,2-乙二胺)二-1-丁醇二盐酸盐
• 英文名: ethambutol dihydrochloride
• 中文别名: 盐酸乙胺丁醇 | 乙胺丁醇二盐酸盐 | (S,S)-2,2'-(1,2-乙二基二亚氨基)双-1-丁醇二盐酸盐 | (S,S)-N,N'-双(1-羟基-2-丁基)乙二胺二盐酸盐

盐酸乙胺丁醇物理化学性质

• 沸点: 345.3ºC at 760 mmHg
• 熔点: 198-200°C
• 分子式: C₁₀H₂₆Cl₂N₂O₂
• 分子量: 277.232
• 闪点: 113.7ºC
• 精确质量: 276.137146
• PSA: 64.52000
• LogP: 2.09320
• 外观性状: 白色粉末
• 蒸汽压: 3.35E-07mmHg at 25°C
• 储存条件: Refrigerator
• 水溶解性: 水溶性：完全溶解；微溶：乙醇；不溶：乙醚

盐酸乙胺丁醇安全信息

• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R61
• 安全声明 (欧洲): S53-S22-S36/37/39-S45
• WGK德国: 3
• RTECS号: EL3854000
• 海关编码: 2922191000

盐酸乙胺丁醇英文别名

• 2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride
• (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride
• (2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride
• (S,S)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol Dihydrochloride
• (2S,2'S)-2,2'-(Ethane-1,2-diyldiimino)dibutan-1-ol dihydrochloride
• Ethambutol hydrochloride
• Ethambutol dihydrochloride
• (2S,2'S)-2,2'-(1,2-Ethanediyldiimino)di(1-butanol) dihydrochloride
• 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-, hydrochloride (1:2)
• MFCD00216025
• EINECS 213-970-7
• 2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride