74-55-5

• 常用中文名：乙胺丁醇
• 常用英文名：Ethambutol
• CAS号：74-55-5
• 分子式：C₁₀H₂₄N₂O₂
• 分子量：204.310
• 相关类别： 原料药 人工合成抗感染类药 抗结核麻风分支杆菌类药
• 发布时间：2018-07-05 13:14:30
• 更新时间：2024-01-02 19:48:10
• Ethambutol是抗分枝杆菌化合物,能通过抑制阿拉伯糖基转移酶活性阻止细胞壁的形成。

名称

• 中文名: 乙胺丁醇
• 英文名: ethambutol
• 英文别名: (S,S)-Et,Et-FerroTANE; (+)-1,1'-BIS[(2R,4R)-2,4-DIETHYLPHOSPHONATO]FERROCENE; R,R-Et-FerroTANE; (S,S)-2,2'-(ethylenediimino)di-1-butanol; (R,R)-ET-FERROTANE(TM); (+)-1,1'-BIS((2R,4R)-2,4-DIETHYLPHOSPHOTANO)FERROCENE; (S,S)-1-[1-(DI-TERT-BUTYLPHOSPHINO)ETHYL]-2-(DIPHENYLPHOSPHINO)FERROCENE; Et-Ferrotane; 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-; Ethambutol; (S)-(+)-1-[(R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE; 2,2'-(1,2-Ethanediyldiimino)di(1-butanol); JOSIPHOS SL-J002-2

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 345.3±22.0 °C at 760 mmHg
• 熔点: 199 - 204ºC
• 分子式: C₁₀H₂₄N₂O₂
• 分子量: 204.310
• 闪点: 113.7±12.9 °C
• 精确质量: 204.183777
• PSA: 64.52000
• LogP: -0.05
• 外观性状: 白色结晶吸湿的粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.478
• 储存条件: 2-8℃
• 分子结构:

  1、 摩尔折射率：58.55

  2、 摩尔体积（cm³/mol）：207.0

  3、 等张比容（90.2K）：514.1

  4、 表面张力（dyne/cm）：38.0

  5、 极化率（10-24cm3）：23.21

生物活性

• 描述: Ethambutol是抗分枝杆菌化合物,能通过抑制阿拉伯糖基转移酶活性阻止细胞壁的形成。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5.

  [2]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain

  [3]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EL3640000 CHEMICAL NAME : 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)- CAS REGISTRY NUMBER : 74-55-5 LAST UPDATED : 199706 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C10-H24-N2-O2 MOLECULAR WEIGHT : 204.36 WISWESSER LINE NOTATION : Q1Y2&M2MY2&1Q -D HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 900 mg/kg/60D-I TOXIC EFFECTS : Liver - jaundice, cholestatic REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,866,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - changes in motor activity (specific assay) Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) Immunological Including Allergic - anaphylaxis REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8700 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1075 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 890 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967

安全

• 海关编码: 2922191000

合成路线

288402-24-4 ~% 74-55-5

文献：Journal of the American Chemical Society, , vol. 122, # 25 p. 5968 - 5976

288402-23-3 ~% 74-55-5

文献：Journal of the American Chemical Society, , vol. 122, # 25 p. 5968 - 5976

909567-52-8 ~78% 74-55-5

文献：Kotkar, Shriram P.; Sudalai, Arumugam Tetrahedron Asymmetry, 2006 , vol. 17, # 11 p. 1738 - 1742

61051-11-4 ~% 74-55-5

文献：Doklady Chemistry, , vol. 145, p. 597 - 600 Doklady Akademii Nauk SSSR, , vol. 145, p. 332 - 335

36697-75-3 ~% 74-55-5

文献：Justus Liebigs Annalen der Chemie, , p. 1455 - 1464

61051-15-8 ~% 74-55-5

文献：Justus Liebigs Annalen der Chemie, , p. 1455 - 1464

147315-16-0 ~% 74-55-5

文献：Tetrahedron, , vol. 58, # 49 p. 9765 - 9767

5856-62-2 107-06-2 ~% 74-55-5

文献：Journal of the American Chemical Society, , vol. 83, p. 2212 - 2213

5856-62-2 106-93-4 ~% 74-55-5

文献：Journal of Medicinal and Pharmaceutical Chemistry, , vol. 5, p. 835 - 845

上下游产品

上游产品  9
288402-24-4 288402-23-3 909567-52-8 61051-11-4
36697-75-3 61051-15-8 5856-62-2 107-06-2
106-93-4
下游产品  1
107-15-3

海关

海关编码	2922191000