舍吲哚
舍吲哚结构式
|
常用名 | 舍吲哚 | 英文名 | SERTINDOLE |
|---|---|---|---|---|
| CAS号 | 106516-24-9 | 分子量 | 440.941 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 592.1±50.0 °C at 760 mmHg | |
| 分子式 | C24H26ClFN4O | 熔点 | 95-100ºC | |
| MSDS | 中文版 美版 | 闪点 | 311.9±30.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
An investigation of the stability of emerging new psychoactive substances.
Drug Test. Anal. 6(7-8) , 696-704, (2014) The evolving nature of new psychoactive substances (NPS) - often referred to as 'legal highs', 'designer drugs' or 'bath salts' - presents an evolving challenge for toxicologists. Apart from the detection and identification of these compounds, further analyti... |
|
|
Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices.
Eur. J. Neurosci. 36(12) , 3628-35, (2012) Agents such as sertindole and astemizole affect heart action by inducing long-QT syndrome, suggesting that apart from their neuronal actions through histamine receptors, 5-HT2 serotonin receptors and D2 dopamine receptors they also affect ether-a-go-go channe... |
|
|
Risperidone versus other atypical antipsychotics for schizophrenia.
Cochrane Database Syst. Rev. (1) , CD006626, (2011) In many countries of the industrialised world second-generation ("atypical") antipsychotics (SGAs) have become the first line drug treatment for people with schizophrenia. The question as to whether and if so how much the effects of the various SGAs differ is... |
|
|
Sertindole in the management of schizophrenia.
J. Cent. Nerv. Syst. Dis. 3 , 75-85, (2011) Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical... |
|
|
Risperidone treatment increases CB1 receptor binding in rat brain.
Neuroendocrinology 91(2) , 155-68, (2010) Body weight gain is a common side effect of treatment with antipsychotics, but the mechanisms underlying this weight gain are unknown. Several factors may be involved in antipsychotic-induced body weight gain including the cannabinoid receptor 1 (CB(1)), the ... |
|
|
The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG.
J. Pharmacol. Exp. Ther. 286(2) , 788-93, (1998) Acquired long QT syndrome is a side effect seen with some pharmacological agents, including antipsychotic drugs, and is associated with the development of ventricular arrhythmias. This syndrome is often caused by the blockade of repolarizing potassium channel... |
|
|
QTc interval prolongation and antipsychotic drug treatments: focus on sertindole.
Int. J. Neuropsychopharmacol. 8(4) , 615-29, (2005) Since the 1960s, physicians have been aware of electrocardiographic (ECG) abnormalities and cases of sudden death associated with the use of antipsychotic drugs in patients with schizophrenia. Explanations for such deaths have traditionally focused on drug-in... |
|
|
DAI-10 is as good as DAI-30 in schizophrenia.
Eur. Neuropsychopharmacol. 22(10) , 747-50, (2012) Drug attitude inventory (DAI-30) is considered to be the best predictor of poor adherence in first-episode schizophrenia. We compared the short version (DAI-10) with DAI-30 in long-term schizophrenia, documented if DAI was associated with poor insight, PANSS ... |
|
|
Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.
J. Clin. Psychopharmacol. 32(2) , 173-8, (2012) Clozapine augmentation with antipsychotic drugs is widely used despite sparse evidence supporting this strategy. Sertindole is a nonsedating atypical antipsychotic drug with low affinity for cholinergic receptors, which makes it potentially suitable for augme... |
|
|
The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers.
J. Psychopharmacol. 25(12) , 1600-13, (2011) Sensory gating, indexed by P50 suppression, and sensorimotor gating, indexed by prepulse inhibition (PPI), are impaired in schizophrenia spectrum disorders. There is considerable evidence that schizophrenia patients treated with atypical antipsychotics exhibi... |