4-羟基苯甲腈
4-羟基苯甲腈结构式
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常用名 | 4-羟基苯甲腈 | 英文名 | 4-Hydroxybenzonitrile |
|---|---|---|---|---|
| CAS号 | 767-00-0 | 分子量 | 119.121 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 281.2±23.0 °C at 760 mmHg | |
| 分子式 | C7H5NO | 熔点 | 110-113 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 123.9±22.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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Formation of trichloronitromethane and dichloroacetonitrile in natural waters: precursor characterization, kinetics and interpretation.
J. Hazard. Mater. 283 , 218-26, (2014) During the chloramination of natural waters, both chloramines and dissolved organic nitrogen (DON) can serve as nitrogen sources for the formation of trichloronitromethane (TCNM) and dichloroacetonitrile (DCAN). The present study investigated the formation ki... |
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Tuning the basicity of cyano-containing ionic liquids to improve SO2 capture through cyano-sulfur interactions.
Chemistry 21(14) , 5632-9, (2015) A new approach has been developed to improve SO2 sorption by cyano-containing ionic liquids (ILs) through tuning the basicity of ILs and cyano-sulfur interaction. Several kinds of cyano-containing ILs with different basicity were designed, prepared, and used ... |
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Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
J. Med. Chem. 48 , 7234-42, (2005) In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspase activity by 50% (I50) and utilized these data to develop ... |
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QSAR study on permeability of hydrophobic compounds with artificial membranes.
Bioorg. Med. Chem. 15 , 3756-67, (2007) We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of structurally diverse compounds with simple physicochemical... |
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Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability.
Pharm. Res. 20(8) , 1267-73, (2003) The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of these surfactant-like molecules... |
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Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Bioorg. Med. Chem. 16 , 7424-8, (2008) Inhibition of 12 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA I-XIV, with a series of phenols was investigated. The inhibition profile by phenols of these CAs was distinct from those of the sulfonamides and their isosteres, ... |
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Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Bioorg. Med. Chem. Lett. 18 , 3593-6, (2008) Inhibition of the newest isoform of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA XV, with a series of phenols was investigated. Murine CA XV showed an inhibition profile by phenols distinct of those of the cytosolic human isoforms CA I and II. Ph... |
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In vitro metabolism of aromatic nitriles.
J. Pharm. Sci. 83(12) , 1729-34, (1994) Studies on the metabolic fate of aromatic nitriles, in contrast to their aliphatic counterparts, have been minimal and the subject of controversy. The in vitro metabolic fate of several aromatic nitriles with varying substituents was investigated by using rat... |
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Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
J. Med. Chem. 50 , 5780-9, (2007) NAD(P)H:quinone oxidoreductase 1 is a proposed target in pancreatic cancer. We describe the synthesis of a series of indolequinones, based on the 5- and 6-methoxy-1,2-dimethylindole-4,7-dione chromophores with a range of phenolic leaving groups at the (indol-... |