4-氟苄基异氰酸酯
4-氟苄基异氰酸酯结构式
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常用名 | 4-氟苄基异氰酸酯 | 英文名 | 4-Fluorobenzyl isocyanate |
|---|---|---|---|---|
| CAS号 | 132740-43-3 | 分子量 | 151.13800 | |
| 密度 | 1.09g/cm3 | 沸点 | 205ºC at 760mmHg | |
| 分子式 | C8H6FNO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 74.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Structure-based design of novel boronic acid-based inhibitors of autotaxin.
J. Med. Chem. 54 , 4619-4626, (2011) Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression, re... |
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Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.
J. Pharmacol. Exp. Ther. 325(3) , 893-901, (2008) Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist to mice or rats. We report here the chemical synthesis and pharmacological characterization of S... |
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