4-Fluorobenzyl isocyanate
4-Fluorobenzyl isocyanate structure
|
Common Name | 4-Fluorobenzyl isocyanate | ||
|---|---|---|---|---|
| CAS Number | 132740-43-3 | Molecular Weight | 151.13800 | |
| Density | 1.09g/cm3 | Boiling Point | 205ºC at 760mmHg | |
| Molecular Formula | C8H6FNO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 74.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Structure-based design of novel boronic acid-based inhibitors of autotaxin.
J. Med. Chem. 54 , 4619-4626, (2011) Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression, re... |
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Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.
J. Pharmacol. Exp. Ther. 325(3) , 893-901, (2008) Neuropeptide S (NPS) has been shown to modulate arousal, sleep wakefulness, anxiety-like behavior, and feeding after central administration of the peptide agonist to mice or rats. We report here the chemical synthesis and pharmacological characterization of S... |
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