环香豆素
环香豆素结构式
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常用名 | 环香豆素 | 英文名 | pyranocoumarin |
|---|---|---|---|---|
| CAS号 | 518-20-7 | 分子量 | 322.35500 | |
| 密度 | 1.27g/cm3 | 沸点 | 488.6ºC at 760 mmHg | |
| 分子式 | C20H18O4 | 熔点 | 166° | |
| MSDS | 中文版 美版 | 闪点 | 216.2ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system.
J. Med. Chem. 27(8) , 1092-5, (1984) An octanol/water model system and circular dichroism (CD) spectroscopy have been used to study the solution conformation of warfarin in aqueous and lipid environments. Upon partitioning of (S)-warfarin from buffer pH 7.4 into octanol, the position of the abso... |
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Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.
Arch. Biochem. Biophys. 372(1) , 16-28, (1999) Possible reasons for the observed differences in metabolic behavior and drug interaction liability between the structurally similar oral anticoagulants warfarin and phenprocoumon were explored. Incubating (S)-phenprocoumon with human liver microsomes and cDNA... |
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Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission.
Acta Virol. 37(4) , 241-50, (1993) A single dose of coumarin derivatives, warfarin, 4-hydroxycoumarin and umbelliferone, added at the time of inoculation either by free virus or by contact with U1 monocytes exhibited a dose-dependent inhibitory effect on viral replication in target MOLT-4 lymp... |