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5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯甲醇

5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯甲醇结构式
5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯甲醇结构式
品牌特惠专场
常用名 5-[2-[(2R,6S)-2,6-二甲基-4-吗啉基]-4-(4-吗啉基)吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯甲醇 英文名 KU-0063794
CAS号 938440-64-3 分子量 465.545
密度 1.2±0.1 g/cm3 沸点 694.3±65.0 °C at 760 mmHg
分子式 C25H31N5O4 熔点 N/A
MSDS 中文版 美版 闪点 373.7±34.3 °C
符号 GHS06
GHS06
信号词 Danger

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

J. Immunol. 193(6) , 2821-30, (2014)

TLR-mediated activation of dendritic cells (DCs) is associated with a metabolic transition in which mitochondrial oxidative phosphorylation is inhibited by endogenously synthesized NO and the cells become committed to glucose and aerobic glycolysis for surviv...