KU-0063794

KU-0063794 Structure
KU-0063794 structure
Common Name KU-0063794
CAS Number 938440-64-3 Molecular Weight 465.545
Density 1.2±0.1 g/cm3 Boiling Point 694.3±65.0 °C at 760 mmHg
Molecular Formula C25H31N5O4 Melting Point N/A
MSDS Chinese USA Flash Point 373.7±34.3 °C
Symbol GHS06
GHS06
Signal Word Danger

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

J. Immunol. 193(6) , 2821-30, (2014)

TLR-mediated activation of dendritic cells (DCs) is associated with a metabolic transition in which mitochondrial oxidative phosphorylation is inhibited by endogenously synthesized NO and the cells become committed to glucose and aerobic glycolysis for surviv...