苹果酸舒尼替尼
苹果酸舒尼替尼结构式
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常用名 | 苹果酸舒尼替尼 | 英文名 | Sunitinib malate |
|---|---|---|---|---|
| CAS号 | 341031-54-7 | 分子量 | 532.561 | |
| 密度 | 1.3600 g/mL at 25 °C(lit.) | 沸点 | 156 °C(lit.) | |
| 分子式 | C26H33FN4O7 | 熔点 | 189-191°C | |
| MSDS | 中文版 美版 | 闪点 | 163 °F | |
| 符号 |
GHS08 |
信号词 | Danger |
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Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST).
Oncotarget 6(4) , 1954-66, (2015) c-Kit/α-PDGFR targeted therapies are effective for gastrointestinal stromal tumors (GIST), but, >50% develop drug resistance.RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (IM) GIST patient samples (n=16) and 4 GIST cell lines ... |
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Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro.
Biomaterials 78 , 115-28, (2015) Formation of new lymphatic vessels, termed lymphangiogenesis, is central for diverse biological processes during development, inflammation and tumor metastasis. However, reliable in vitro model is still under demand for detailed elucidation of how sprouting l... |
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Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells.
J. Pharmacol. Sci. 128 , 17-26, (2015) Connexin (Cx) makes up a type of intercellular channel called gap junction (GJ). GJ plays a regulatory role in cellular physiology. The Cx expression level is often decreased in cancer cells compared to that in healthy ones, and the restoration of its express... |
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Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.
J. Biol. Chem. 290 , 22061-75, (2015) Transfer of cardiac progenitor cells (CPCs) improves cardiac function in heart failure patients. However, CPC function is reduced with age, limiting their regenerative potential. Aging is associated with numerous changes in cells including accumulation of mit... |
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Detecting functional changes with [(18)F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy.
EJNMMI Res. 4 , 27, (2015) The multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to modifications of the tumor microenvironment. The g... |
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AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
J. Virol. 89(8) , 4387-404, (2015) Hepatitis C virus (HCV) enters its target cell via clathrin-mediated endocytosis. AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocytic a... |
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Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs.
BMC Cancer 14 , 722, (2014) Cancer stem cells (CSCs) are thought to play important roles in therapy-resistance. In this study, we induced cancer stem-like cells from hepatocellular carcinoma (HCC) cell lines using a unique medium, and examined their potential for resistance to anti-canc... |
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Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies.
Biomed. Chromatogr. 29 , 679-88, (2015) A simple, sensitive and specific method using ultraperformance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was developed to determine sunitinib and N-desethyl sunitinib in mouse plasma and tissues. The analytes were separated by an isocratic m... |
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Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.
BMC Cancer 14 , 939, (2014) Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on diff... |
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Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation.
Oncotarget 6 , 11295-309, (2015) Different mechanisms of angiogenesis and vasculogenesis are involved in the development of the tumor vasculature. Among them, cancer stem cells are known to contribute to tumor vasculogenesis through their direct endothelial differentiation. Here, we investig... |