6,6'-二硫二烟酸
6,6'-二硫二烟酸结构式
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常用名 | 6,6'-二硫二烟酸 | 英文名 | 3-Pyridinecarboxylicacid, 6,6'-dithiobis- |
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| CAS号 | 15658-35-2 | 分子量 | 308.33 | |
| 密度 | 1.66g/cm3 | 沸点 | 584.2ºC at 760mmHg | |
| 分子式 | C12H8N2O4S2 | 熔点 | 263-265 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 307.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).
Chemioterapia 5(4) , 219-27, (1986) We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo highly metastatic subline of murine B16 melanoma (F10). CPDS... |
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Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid.
Anal. Biochem. 138(1) , 95-8, (1984) A simple and rapid method for the determination of nanomole levels of biological thiols is described. The analysis is based on the combination of reverse-phase high-performance liquid chromatography with a postcolumn reaction with 6,6'-dithiodinicotinic acid.... |
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Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system.
Biochem. J. 213(3) , 587-94, (1983) The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gastric (H+ + K+)-transporting ATPase system was investigated. ... |
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The action of myocrisin on membrane bound sulphhydryl groups.
Clin. Chim. Acta 195(1-2) , 41-5, (1990)
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Activation of intestinal brush border guanylate cyclase by aromatic disulphide compounds.
Biochem. J. 275 ( Pt 1) , 29-34, (1991) Guanylate cyclase in pig intestinal brush border membranes was stimulated by certain aromatic disulphides. The most effective were 6-thioguanine disulphide [(TGS)2], 6-mercaptopurine disulphide, 6,6'-dithiodinicotinic acid, 5,5'-dithiobis-(2-nitrobenzoic acid... |
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Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species.
Toxicol. Mech. Methods 21(7) , 533-7, (2011) For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Usually, this testing is done with the colorimetric Ellman test using 412 nm wavele... |
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Metastases limited.
Nature 308(5959) , 500, (1984)
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The determination of thiols and of total glutathione in human blood using 6,6'-dithiodinicotinic acid (CPDS).
Biochem. Med. 12(2) , 149-53, (1975)
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The interaction of 6,6'-dithiodinicotinic acid with thiols and with ehrlich ascites tumor cells.
Biochem. Pharmacol. 18(3) , 603-11, (1969)
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[Dependence of the radioprotective effect of beta-mercaptoethylamine on the thiol level of the outer cell membrane].
Radiobiologiia 29(2) , 280-2, (1989) In experiments with Ehrlich ascites tumor cells with the use of a specific thiol blocker, 6,6'-dithiodinicotinic acid, it was shown that thiols of a cell plasmic membrane are necessary for the radioprotective effect of mercaptoethylamine to be realized. |