3-Pyridinecarboxylicacid, 6,6'-dithiobis-

Modify Date: 2024-01-10 00:05:07

3-Pyridinecarboxylicacid, 6,6'-dithiobis- Structure
3-Pyridinecarboxylicacid, 6,6'-dithiobis- structure
Common Name 3-Pyridinecarboxylicacid, 6,6'-dithiobis-
CAS Number 15658-35-2 Molecular Weight 308.33
Density 1.66g/cm3 Boiling Point 584.2ºC at 760mmHg
Molecular Formula C12H8N2O4S2 Melting Point 263-265 °C(lit.)
MSDS Chinese USA Flash Point 307.1ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of 3-Pyridinecarboxylicacid, 6,6'-dithiobis-


6,6′-Dithiodinicotinic acid is a sulfur-containing organic compound belonging to nicotinic acid derivatives, which can be used as a specific sulfhydryl blocker[1].

 Names

Name 6,6'-dithiodinicotinic acid
Synonym More Synonyms

  Biological Activity

Description 6,6′-Dithiodinicotinic acid is a sulfur-containing organic compound belonging to nicotinic acid derivatives, which can be used as a specific sulfhydryl blocker[1].
Related Catalog
References

[1]. Samir Abou-Khalil, et al. Effects of 6,6′-dithiodinicotinic acid, a thiol reagent on several mitochondrial functions: Coupling mechanism, ATPase and anion transport.Biochemical Pharmacology.Volume 24, Issue 1, 1 January 1975, Pages 49-56.

 Chemical & Physical Properties

Density 1.66g/cm3
Boiling Point 584.2ºC at 760mmHg
Melting Point 263-265 °C(lit.)
Molecular Formula C12H8N2O4S2
Molecular Weight 308.33
Flash Point 307.1ºC
Exact Mass 307.99300
PSA 150.98000
LogP 2.67240
Vapour Pressure 1.71E-14mmHg at 25°C
Index of Refraction 1.753
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5684700
CHEMICAL NAME :
3-Pyridinecarboxylic acid, 6,6'-dithiobis-
CAS REGISTRY NUMBER :
15658-35-2
BEILSTEIN REFERENCE NO. :
0426589
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H8-N2-O4-S2
MOLECULAR WEIGHT :
308.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,559,1986

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS US5684700
HS Code 2933399090

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles22

More Articles
Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).

Chemioterapia 5(4) , 219-27, (1986)

We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo h...

Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid.

Anal. Biochem. 138(1) , 95-8, (1984)

A simple and rapid method for the determination of nanomole levels of biological thiols is described. The analysis is based on the combination of reverse-phase high-performance liquid chromatography w...

Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system.

Biochem. J. 213(3) , 587-94, (1983)

The distribution of free thiol groups associated with the membrane proteins of the purified pig gastric microsomal vesicles was quantified, and the relation of thiol groups to the function of the gast...

 Synonyms

MFCD00006454
6,6'-Dithiobis(3-pyridinecarboxylic Acid)
EINECS 239-729-6
6,6'-Dithiodinicotinic Acid
6-[(5-carboxypyridin-2-yl)disulfanyl]pyridine-3-carboxylic acid