波尔定碱
波尔定碱结构式
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常用名 | 波尔定碱 | 英文名 | Boldine |
|---|---|---|---|---|
| CAS号 | 476-70-0 | 分子量 | 327.374 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 529.3±50.0 °C at 760 mmHg | |
| 分子式 | C19H21NO4 | 熔点 | 162-164ºC | |
| MSDS | 中文版 美版 | 闪点 | 273.9±30.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine.
Molecules 17(9) , 10958-70, (2012) The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, toxicity and singlet oxygen photosensitization biological pro... |
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Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.
Planta Med. 72(12) , 1157-62, (2006) The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in the quantitative assay for the respective herbal drugs. The... |
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8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes.
Planta Med. 71(10) , 897-903, (2005) Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human alpha (1A), alpha (1B) and alpha (1D) adrenoceptors (AR) using membranes prepared from rat-1 fibroblasts stably expressing each alpha (1)-AR s... |
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The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells.
J. Med. Food 12(5) , 1074-83, (2009) Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease. Natural compounds that can preven... |
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Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.
Bioorg. Med. Chem. 15(10) , 3368-72, (2007) (S)-Aporphine metho salts with the 1,2,9,10 oxygenation pattern displaced radioligands from recombinant human alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors (nAChR) at low micromolar concentrations. The affinity of the nonphenolic glaucine ... |
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Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver.
Phytother Res. 23(7) , 1024-7, (2009) Peumus boldus Molina (Monimiaceae), commonly referred to as 'boldo', is used in traditional Chilean medicine to treat hepatic and gastrointestinal diseases. Its leaves are rich in antioxidant compounds, principally alkaloids and flavonoids. This study evaluat... |
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Spectroscopic study of antileishmanial drug incubated in the promastigotes of Leishmania mexicana.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 59(13) , 3177-83, (2003) In this work we present spectroscopic study of Boldine (aporphine alkaloid) that possesses important biological activities, in particular, in interaction with the promastigotes of Leishmania mexicana. The results show the applicability of autofluorescence of ... |
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Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC-MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 936 , 48-56, (2013) Boldine belongs to the group of aporphine alkaloids isolated from Boldo tree. In contrast with numerous reports on the pharmacological effects of boldine, the data about its pharmacokinetics and biotransformation are scarce. No validated bioanalytical method ... |
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Photostability and photoprotection factor of boldine and glaucine.
J. Photochem. Photobiol. B, Biol. 80(1) , 65-9, (2005) Boldine hydrochloride was more photounstable than boldine after irradiation with UVB (lambda = 300 nm). However, photoconsumption quantum yields, for glaucine hydrochloride (6.5 x 10(-2)) and boldine hydrochloride (6.7 x 10(-2)) in air, were quite similar. Th... |
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5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis.
Phytother Res. 23(3) , 330-4, (2009) A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two co... |