Boldine

Modify Date: 2024-01-02 21:25:03

Boldine structure	Common Name	Boldine
	CAS Number	476-70-0	Molecular Weight	327.374
	Density	1.3±0.1 g/cm3	Boiling Point	529.3±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₁NO₄	Melting Point	162-164ºC
	MSDS	Chinese USA	Flash Point	273.9±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Boldine

Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].

Name	(6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
Synonym	More Synonyms

Description	Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	OPG/RANKL/RANK[1]
References	[1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123.

Density	1.3±0.1 g/cm3
Boiling Point	529.3±50.0 °C at 760 mmHg
Melting Point	162-164ºC
Molecular Formula	C₁₉H₂₁NO₄
Molecular Weight	327.374
Flash Point	273.9±30.1 °C
Exact Mass	327.147064
PSA	62.16000
LogP	2.32
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.639

Boldine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE0750000

CHEMICAL NAME :: 6a-alpha-Aporphine-2,9-diol, 1,10-dimethoxy-

CAS REGISTRY NUMBER :: 476-70-0

BEILSTEIN REFERENCE NO. :: 0094036

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J EO1 FQ K1 PQ QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 100 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,145,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	1-20-24/25-45-36-26
RIDADR	UN 1544
WGK Germany	3
RTECS	CE0750000
Packaging Group	III
Hazard Class	6.1(b)

Formaldehyde

CAS#:50-00-0

Formic Acid

CAS#:64-18-6

Boldine

CAS#:476-70-0

Literature: Nakasato; Nomura Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 780,784 Chem.Abstr., 1960 , p. 4646

Precursor 2
CAS#:50-00-0 Formaldehyde CAS#:64-18-6 Formic Acid
DownStream 1
CAS#:475-81-0 Glaucine

Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine.

Molecules 17(9) , 10958-70, (2012)

The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, to...

Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

Planta Med. 72(12) , 1157-62, (2006)

The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in ...

8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes.

Planta Med. 71(10) , 897-903, (2005)

Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human alpha (1A), alpha (1B) and alpha (1D) adrenoceptors (AR) using membranes prepared f...

Boldine chloroform

4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-

Boldin

2,6-dihydroxy-3,5-dimethoxyaporphine

5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol

EINECS 207-509-9

1,10-dimethoxy-2,9-dihydroxyaporphine

Uniboldina

MFCD00135040

2,9-Dihydroxy-1,10-dimethoxyaporphine

1,10-Dimethoxy-6aa-aporphine-2,9-diol

dl-Boldine

Boldine

1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol

BioBioPha
China
Product Name: Boldine
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Boldine
Price: ￥888.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Boldine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Boldine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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