缬沙坦

缬沙坦结构式
缬沙坦
常用名 缬沙坦 英文名 Valsartan
CAS号 137862-53-4 分子量 435.519
密度 1.2±0.1 g/cm3 沸点 684.9±65.0 °C at 760 mmHg
分子式 C24H29N5O3 熔点 116-117°C
MSDS缬沙坦的MSDS|SDS|pdf下载 美版 闪点 368.0±34.3 °C

A lab-on-a-chip device for analysis of amlodipine in biological fluids using peroxyoxalate chemiluminescence system.

Luminescence 29(8) , 1148-53, (2014)

A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows t...

Development and Validation of a LC-MS/MS Method for the Simultaneous Estimation of Amlodipine and Valsartan in Human Plasma: Application to a Bioequivalence Study.

Sci. Pharm. 82(3) , 585-600, (2015)

A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric (LC-MS/MS) method has been developed and validated that employs solid-phase extraction for the simultaneous estimation of amlodipine and valsartan in human K3EDTA plasma using aml...

Comparative study between derivative spectrophotometry and multivariate calibration as analytical tools applied for the simultaneous quantitation of Amlodipine, Valsartan and Hydrochlorothiazide.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 113 , 215-23, (2013)

Four simple, accurate and specific methods were developed and validated for the simultaneous estimation of Amlodipine (AML), Valsartan (VAL) and Hydrochlorothiazide (HCT) in commercial tablets. The derivative spectrophotometric methods include Derivative Rati...

Valsartan plus hydrochlorothiazide: a review of its use since its introduction.

Expert Opin. Pharmacother. 12(12) , 1975-84, (2011)

This review focuses on the role of the fixed-dose combination (FDC) drug valsartan/hydrochlorothiazide (HCTZ) in the treatment of hypertension. Effective blood pressure control often is not achieved with monotherapy and, instead, requires combinations of drug...

Telmisartan or valsartan alone or in combination with hydrochlorothiazide: a review.

Clin. Exp. Hypertens. 35(1) , 50-60, (2013)

The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, a...

Negligible Pharmacokinetic Interaction of Red Ginseng and Losartan, an Antihypertensive Agent, in Sprague-Dawley Rats.

J. Toxicol. Environ. Health A 78 , 1299-309, (2015)

Red ginseng (RG) is one of the top selling herbal medicines in Korea, but is not recommended in hypertensive patients. In this study, the pharmacokinetic (PK) interaction between RG and losartan, an antihypertensive drug, was examined. RG was orally administe...

Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2.

Cardiovasc. Drugs Ther. 29 , 209-18, (2015)

Myocardial infarction (MI) results in an increased susceptibility to ventricular arrhythmias, due in part to decreased inward-rectifier K+ current (IK1), which is mediated primarily by the Kir2.1 protein. The use of renin-angiotensin-aldosterone system antago...

Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: preclinical assessment of pharmacokinetics in Wistar albino rats.

Expert Opin. Drug Deliv. 11(8) , 1149-62, (2014)

The aim of this study was to develop and optimize a transdermal gel formulation of valsartan using Box-Behnken design and to evaluate it for pharmacokinetic study.The independent variables were Carbopol 940 (X1), PEG 400 (X2) and ethanol (X3) while valsartan ...

Incidence of atrial fibrillation in a population with impaired glucose tolerance: The contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial

Am. Heart J. 166(5) , 935-40.e1, (2013)

Background The role of dysglycemia as an additional risk factor for atrial fibrillation (AF) is controversial. Therefore, it was of interest to assess risk factors for incident AF in a large, representative population of patients with cardiovascular risk fact...

Role of diuretics, _ blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study.

BMJ 347 , f6745, (2013)

To examine the degree to which use of _ blockers, statins, and diuretics in patients with impaired glucose tolerance and other cardiovascular risk factors is associated with new onset diabetes.