氨己烯酸
氨己烯酸结构式
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常用名 | 氨己烯酸 | 英文名 | Vigabatrin |
|---|---|---|---|---|
| CAS号 | 60643-86-9 | 分子量 | 129.157 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 277.7±28.0 °C at 760 mmHg | |
| 分子式 | C6H11NO2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 121.7±24.0 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.
JAMA Psychiatry 70(6) , 630-7, (2013) Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conduc... |
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Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function.
Brain. Behav. Immun. 27(1) , 80-90, (2013) Our previous work has shown that the cerebellar fastigial nucleus (FN) is involved in modulation of lymphocyte function. Herein, we investigated effect of FN γ-aminobutyric acid (GABA)-ergic projections to the hypothalamus on lymphocytes to understand pathway... |
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Vigabatrin versus carbamazepine monotherapy for epilepsy.
Cochrane Database Syst. Rev. 1 , CD008781, (2012) The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual field defects. Whether VGB monotherapy is an effective and safe... |
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Changes in the ERG d-wave with vigabatrin treatment in a pediatric cohort.
Doc. Ophthalmol. 129(2) , 97-104, (2014) Vigabatrin (VGB), a treatment for the childhood epilepsy, infantile spasms (IS), is implicated in visual field constriction. Electroretinograms (ERGs) are used as a substitute for visual field testing in infants. We use the VGB-associated ERG reduction (VAER)... |
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Vigabatrin-associated retinal damage: potential biochemical mechanisms.
Acta Neurol. Scand 126(4) , 219-28, (2012) Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the ri... |
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Recommendations for visual evaluations of patients treated with vigabatrin.
Curr. Opin. Ophthalmol. 21(6) , 442-6, (2010) Although vigabatrin has been used for many years in Europe, this antiepileptic medication was approved for use in the USA only 1 year ago because of concerns for irreversible peripheral visual field loss that can result in functional visual disability.Visual ... |
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Balancing clinical benefits of vigabatrin with its associated risk of vision loss.
Acta Neurol. Scand.,. Suppl.c. (192) , 83-91, (2011) Vigabatrin is an effective and well-tolerated antiepileptic drug (AED) for the treatment of refractory complex partial seizures (rCPS) and infantile spasms (IS), but its benefits must be evaluated in conjunction with its risk of retinopathy with the developme... |
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Vigabatrin for infantile spasms.
Pharmacotherapy 31(3) , 298-311, (2011) Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroen... |
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Vigabatrin for refractory partial epilepsy.
Cochrane Database Syst. Rev. 1 , CD007302, (2013) Epilepsy is a common neurological condition which affects between 0.5% and 1% of the population. Approximately 30% of people with epilepsy do not respond to treatment with currently available drugs. The majority of these people have partial epilepsy. Vigabatr... |
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Justification of vigabatrin administration in West syndrome patients? Warranting a re-consideration for improvement in their quality of life
Clin. Neurol. Neurosurg. 111(2) , 111-4, (2009) West syndrome (WS) or infantile spasms (IS) is a severe epileptic syndrome associated with poor prognosis and increased morbidity. The exact etio-pathogenesis of the disorder still remains elusive ant therefore the management continues to pose a challenge to ... |