司帕沙星
司帕沙星结构式
|
常用名 | 司帕沙星 | 英文名 | Sparfloxacin |
|---|---|---|---|---|
| CAS号 | 110871-86-8 | 分子量 | 392.400 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 640.4±55.0 °C at 760 mmHg | |
| 分子式 | C19H22F2N4O3 | 熔点 | 265°C | |
| MSDS | 中文版 美版 | 闪点 | 341.1±31.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
|
New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate.
Antimicrob. Agents Chemother. 51 , 3354-60, (2007) Plasmid-mediated Qnr and AAC(6')-Ib-cr have been recognized as new molecular mechanisms affecting fluoroquinolone (FQ) resistance. C316, an Escherichia coli strain demonstrating resistance to various FQs, was isolated in Japan. Resistance to FQs was augmented... |
|
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Interactions of a non-fluorescent fluoroquinolone with biological membrane models: A multi-technique approach.
Int. J. Pharm. 495 , 761-70, (2015) Fluoroquinolones are antibiotics which act by penetrating into bacterial cells and inhibiting enzymes related to DNA replication, and metal complexes of these drugs have recently been investigated as one approach to counteracting bacterial resistance. In this... |
|
|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
J. Med. Chem. 51 , 3275-87, (2008) The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and drug-like compounds. The data set included a new reference set... |
|
|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
J. Med. Chem. 53 , 3566-84, (2010) The study aimed to predict effective human jejunal permeability (P(eff)) using a biophysical model based on parametrized paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surface area expansion factor (k(VF)). Publish... |
|
|
QSAR-based solubility model for drug-like compounds.
Bioorg. Med. Chem. 18 , 7078-84, (2010) Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemi... |
|
|
The permeation of amphoteric drugs through artificial membranes--an in combo absorption model based on paracellular and transmembrane permeability.
J. Med. Chem. 53 , 392-401, (2010) The permeability characteristics of 33 amphoteric drugs (about 64% zwitterions at physiological pH) were studied using the parallel artificial membrane permeability assay (PAMPA) at pH 6.5. The PAMPA data were modified to include the paracellular permeability... |
|
|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug Metab. Dispos. 36 , 1385-405, (2008) We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data. This data set provides the drug metabolism scientist ... |
|
|
Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.
Environ. Sci. Pollut. Res. Int. 22 , 16857-67, (2015) An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tet... |
|
|
Characterization of Salmonella Typhimurium DNA gyrase as a target of quinolones.
Drug Test. Anal. 7 , 714-20, (2015) Quinolones exhibit good antibacterial activity against Salmonella spp. isolates and are often the choice of treatment for life-threatening salmonellosis due to multi-drug resistant strains. To assess the properties of quinolones, we performed an in vitro assa... |