2,4-二氨基嘧啶
2,4-二氨基嘧啶结构式
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常用名 | 2,4-二氨基嘧啶 | 英文名 | 2,4-Diaminopyrimidine |
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| CAS号 | 156-81-0 | 分子量 | 110.117 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 401.7±37.0 °C at 760 mmHg | |
| 分子式 | C4H6N4 | 熔点 | 143-147 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 225.6±13.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.
Neuropharmacology 99 , 422-31, (2015) Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concen... |
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Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents.
Eur. J. Med. Chem. 96 , 269-80, (2015) Therapeutics of metastatic or triple-negative breast cancer are still challenging in clinical. Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properti... |
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Cocrystals of 6-methyl-2-thiouracil: presence of the acceptor-donor-acceptor/donor-acceptor-donor synthon.
Acta Crystallogr. C Struct. Chem. 71(Pt 3) , 229-38, (2015) The results of seven cocrystallization experiments of the antithyroid drug 6-methyl-2-thiouracil (MTU), C(5)H(6)N(2)OS, with 2,4-diaminopyrimidine, 2,4,6-triaminopyrimidine and 6-amino-3H-isocytosine (viz. 2,6-diamino-3H-pyrimidin-4-one) are reported. MTU fea... |
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Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters.
Anal. Bioanal. Chem 393(6-7) , 1709-18, (2009) An ultra performance liquid chromatography electrospray tandem mass spectrometry (UPLC/MS/MS) method was developed and validated for the determination of 17 antibiotics in natural waters in one single extraction and chromatographic procedure. Gradient separat... |
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Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.
Antimicrob. Agents Chemother. 51(6) , 2268-73, (2007) Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) th... |
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The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.
J. Biol. Chem. 285(16) , 12101-8, (2010) The acyclic pyrimidine nucleoside phosphonate (ANP) phosphonylmethoxyethoxydiaminopyrimidine (PMEO-DAPym) differs from other ANPs in that the aliphatic alkyloxy linker is bound to the C-6 of the 2,4-diaminopyrimidine base through an ether bond, instead of the... |
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Effect of substituents on the excited-state dynamics of the modified DNA bases 2,4-diaminopyrimidine and 2,6-diaminopurine.
Phys. Chem. Chem. Phys. 12(20) , 5375-88, (2010) To explore the excited state dynamics of pyrimidine derivatives, we performed a combined experimental and theoretical study. We present resonant two-photon ionization (R2PI) and IR-UV double resonance spectra of 2,4-diaminopyrimidine and 2,6-diaminopurine see... |
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Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat. Chem. Biol. 8(3) , 246-52, (2012) Signal transduction, regulatory processes and pharmaceutical responses are highly dependent upon ligand residence times. Gaining insight into how physical factors influence residence times (1/k(off)) should enhance our ability to manipulate biological interac... |
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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach.
PLoS Negl. Trop. Dis. 5(2) , e956, (2011) There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, ex... |
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2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
J. Med. Chem. 49(8) , 2568-78, (2006) Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrel... |