神经降压素(8-13)
神经降压素(8-13)结构式
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常用名 | 神经降压素(8-13) | 英文名 | Neurotensin (8-13) acetate salt |
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| CAS号 | 60482-95-3 | 分子量 | 816.99000 | |
| 密度 | 1.4 g/cm3 | 沸点 | N/A | |
| 分子式 | C38H64N12O8 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier.
Neuropharmacology 48(3) , 417-25, (2005) A set of neurotensin[8-13] (NT[8-13]) analogues (KK1-19) has been evaluated in various pre-clinical assays relevant for further development of these compounds as potential antipsychotics. Initial screening of these compounds for induction of hypothermia follo... |
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The neurotensin fragment AcNT(8-13) inhibits lowering of interstitial fluid pressure in rat trachea.
Am. J. Physiol. Heart Circ. Physiol. 283(3) , H933-40, (2002) Injury to soft tissue results in the lowering of interstitial fluid pressure (P(if)), plasma protein extravasation, and increased total tissue volume. In this study, the effects of N-acetyl neurotensin(8-13) [AcNT(8-13)] on P(if) in rat trachea were examined ... |
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Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18.
Appl. Radiat. Isot. 65(7) , 818-26, (2007) Three methods for (18)F-labeling of dimeric and tetrameric neurotensin(8-13) derivatives were evaluated with respect to the labeling yield and the required peptide amounts. Labeling using N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) gave low radiochemi... |
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Gq/11-induced and spontaneous waves of coordinated network activation in developing frontal cortex.
J. Neurosci. 25(7) , 1737-49, (2005) Repeated episodes of spontaneous large-scale neuronal bursting and calcium influx in the developing brain can potentially affect such fundamental processes as circuit formation and gene expression. Between postnatal day 3 (P3) and P7, the immature cortex can ... |
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Radionuclide imaging of small-cell lung cancer (SCLC) using 99mTc-labeled neurotensin peptide 8-13.
Nucl. Med. Biol. 33(4) , 505-12, (2006) To prepare 99m technetium (99mTc)-labeled neurotensin (NT) peptide and to evaluate the feasibility of imaging oncogene NT receptors overexpressed in human small-cell lung cancer (SCLC) cells.The NT analogue (Nalpha-His)Ac-NT(8-13) was synthesized such that hi... |
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Separation and determination of peptide hormones by capillary electrophoresis with laser-induced fluorescence coupled with transient pseudo-isotachophoresis preconcentration.
Anal. Biochem. 380(2) , 297-302, (2008) A new method for the determination of the peptide hormones and their fragments by capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection and transient pseudo-isotachophoresis (pseudo-tITP) preconcentration was established in this study... |
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Monitoring neurotensin[8-13] degradation in human and rat serum utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Anal. Biochem. 308(1) , 34-41, (2002) A method was developed to quantify neurotensin (NT) fragment [8-13] and a novel NT[8-13] derivative, KK1, in human and rat serum utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). The method allows for simult... |
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Synthesis and evaluation of novel multimeric neurotensin(8-13) analogs.
Bioorg. Med. Chem. 14(17) , 5913-20, (2006) Neurotensin(8-13) is a hexapeptide with subnanomolar affinity to the neurotensin receptor 1 which is expressed with high incidence in several human tumor entities. Thus, radiolabeled neurotensin(8-13) might be used for tumor targeting. However, its applicatio... |
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Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs.
J. Pept. Res. 59(2) , 55-61, (2002) A series of neurotensin (NT)(8-13) analogs featuring substitution of the Arg8 and/or Arg9 residues with non-natural cationic amino acids was synthesized and evaluated for binding to the human NT receptor-1 (hNTR-1). The modifications were designed to probe sp... |
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Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators.
Nucl. Med. Biol. 38(1) , 113-20, (2011) Several strategies on the development of radiopharmaceuticals have been employed. Bifunctional chelators seem to be a promising approach since high radiochemical yields as well as good in vitro and in vivo stability have been achieved. To date, neurotensin an... |