扎鲁司特
扎鲁司特结构式
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常用名 | 扎鲁司特 | 英文名 | Zafirlukast |
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| CAS号 | 107753-78-6 | 分子量 | 575.675 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C31H33N3O6S | 熔点 | 139°C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.
Antimicrob. Agents Chemother. 59(1) , 633-41, (2014) Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infecti... |
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Rapid determination of canagliflozin in rat plasma by UHPLC-MS/MS using negative ionization mode to avoid adduct-ions formation.
Talanta 132 , 29-36, (2014) Canagliflozin is the first sodium-glucose co-transporter-2 inhibitor, approved by the US Food and Drug Administration for the treatment of type 2 diabetes mellitus. In this study, a sensitive UHPLC-MS/MS assay for rapid determination of canagliflozin in rat p... |
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Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase.
Am. J. Physiol. Cell Physiol. 305(1) , C48-60, (2013) Pathophysiological conditions challenge cell volume homeostasis and perturb cell volume regulatory mechanisms leading to alterations of cell metabolism, active transepithelial transport, cell migration, and death. We report that inhibition of the 5-lipoxygena... |
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Differential inhibitory effects of CysLT(1) receptor antagonists on P2Y(6) receptor-mediated signaling and ion transport in human bronchial epithelia.
PLoS ONE 6 , e22363, (2011) Cysteinyl leukotriene (CysLT) is one of the proinflammatory mediators released by the bronchi during inflammation. CysLTs exert their biological effects via specific G-protein-coupled receptors. CysLT(1) receptor antagonists are available for clinical use for... |
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Identification of novel functional inhibitors of acid sphingomyelinase.
PLoS ONE 6 , e23852, (2011) We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat di... |
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Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast.
Drug Metab. Dispos. 43 , 812-8, (2015) Inhibition of drug metabolizing enzymes is a major mechanism in drug-drug interactions (DDIs). A number of cases of DDIs via inhibition of UDP-glucuronosyltranseferases (UGTs) have been reported, although the changes in pharmacokinetics are relatively small i... |
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Identification, characterization and synthesis of impurities of zafirlukast.
J. Pharm. Biomed. Anal. 49(4) , 895-900, (2009) Zafirlukast is a drug in the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, five unknown impurities were detected at levels of below 0.10% (ranging from 0.05 to 0.15%) in reverse phase gradient high performance... |
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Zafirlukast pocket delivery impairs the capsule healing around textured implants in rats.
Aesthetic Plast. Surg. 33(1) , 90-7, (2009) The aim of this study was to investigate the effects of zafirlukast on capsule thickness, collagen fiber density, and myofibroblast cell count of the healing tissue around silicone textured implants in rats.Thirty-six male Wistar rats were divided (n = 18) in... |
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Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats.
J. Feline Med. Surg. 12(10) , 754-9, (2010) This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT(1)) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10mg, PO) and endotoxin (2 μg/kg/h q 6h) in a... |
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Zafirlukast for chronic asthma: convenient and generally safe, but is it effective?
Ann. Pharmacother. 31(9) , 1084-6, (1997)
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