4-甲基-3-硝基苯甲酰氯
4-甲基-3-硝基苯甲酰氯结构式
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常用名 | 4-甲基-3-硝基苯甲酰氯 | 英文名 | 4-Methyl-3-nitrobenzoyl chloride |
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| CAS号 | 10397-30-5 | 分子量 | 199.59100 | |
| 密度 | 1.37 g/mL at 25 °C(lit.) | 沸点 | 185 °C36 mm Hg(lit.) | |
| 分子式 | C8H6ClNO3 | 熔点 | 20-21 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | >230 °F | |
| 符号 |
GHS05 |
信号词 | Danger |
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New low-density lipoprotein receptor upregulators acting via a novel mechanism.
J. Med. Chem. 39(17) , 3343-56, (1996) The synthesis and biological activity of a new series of benzamides and related compounds that upregulate the expression of the low-density lipoprotein (LDL) receptor in human hepatocytes (HepG2 cells) by a novel mechanism are described. The lead compound, N-... |
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Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
PLoS ONE 9(3) , e91765, (2014) Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant ... |
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Design, synthesis and biological evaluation of novel acrylamide analogues as inhibitors of BCR-ABL kinase.
Bioorg. Med. Chem. Lett. 22(16) , 5279-82, (2012) A series of acrylamide analogues were designed and synthesized from Imatinib and Nilotinib as novel BCR-ABL inhibitors by application of the principle of nonclassical electronic isostere. All new compounds were evaluated for their inhibitory effects on the ac... |
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N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Bioorg. Med. Chem. Lett. 18(3) , 1172-6, (2008) N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activ... |
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Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors
Bioorg. Med. Chem. Lett. 18 , 4713-5, (2008) Two new series of benzonitrile derivatives on position 6 or 4 of the indole ring were successfully synthesized via a Leimgruber–Batcho reaction. The target compounds were further evaluated as aromatase inhibitors. |