Bioorganic & Medicinal Chemistry Letters 2008-01-01

Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors

Marie-Pierre Lézé, Anja Palusczak, Rolf W. Hartmann, Marc Le Borgne, Marie-Pierre Lézé, Anja Palusczak, Rolf W. Hartmann, Marc Le Borgne

文献索引：Bioorg. Med. Chem. Lett. 18 , 4713-5, (2008)

全文：HTML全文

摘要

Two new series of benzonitrile derivatives on position 6 or 4 of the indole ring were successfully synthesized via a Leimgruber–Batcho reaction. The target compounds were further evaluated as aromatase inhibitors.