Bioorganic & Medicinal Chemistry Letters 2008-01-01

Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors

Marie-Pierre Lézé, Anja Palusczak, Rolf W. Hartmann, Marc Le Borgne, Marie-Pierre Lézé, Anja Palusczak, Rolf W. Hartmann, Marc Le Borgne

Index: Bioorg. Med. Chem. Lett. 18 , 4713-5, (2008)

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Abstract

Two new series of benzonitrile derivatives on position 6 or 4 of the indole ring were successfully synthesized via a Leimgruber–Batcho reaction. The target compounds were further evaluated as aromatase inhibitors.