Adenosine 5'-(γ-thio)-triphosphate (lithium salt)
Adenosine 5'-(γ-thio)-triphosphate (lithium salt)结构式
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常用名 | Adenosine 5'-(γ-thio)-triphosphate (lithium salt) | 英文名 | Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt |
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| CAS号 | 93839-89-5 | 分子量 | 546.979 | |
| 密度 | N/A | 沸点 | 940.5ºC at 760 mmHg | |
| 分子式 | C10H12Li4N5O12P3S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 522.6ºC |
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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.
J. Mol. Biol. 426(15) , 2886-99, (2014) The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form... |
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The enzymatic synthesis of thiophosphate analogs of nucleotides.
Biochim. Biophys. Acta 276 , 155, (1972)
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ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.
Cell 144 , 526-538, (2011) In the eukaryotic 26S proteasome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous ring complex, PAN. To clarify the role of ATP in proteolysis, we studied how nucleotides bind to PAN. Although PAN has six identical su... |
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ATP-Dependent Steps in the Binding of Ubiquitin Conjugates to the 26S Proteasome that Commit to Degradation
Mol. Cell. 40 , 671-781, (2010) Eukaryotic cells target proteins for degradation by the 26S proteasome by attaching a ubiquitin chain. Using a rapid assay, we analyzed the initial binding of ubiquitinated proteins to purified 26S particles as an isolated process at 4°C. Subunits Rpn10 and R... |
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The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate).
J. Biol. Chem. 258 , 12624, (1983) recA protein binds to duplex DNA in the presence of Mg2+ and adenosine 5'-O-(3-thiotriphosphate) forming a stiff nucleoprotein filament with a distinct axial repeat which contains 17 +/- 1 base pairs and spans 8-9 nm along the fiber (Di Capua, E., Engel, A., ... |
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Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia.
J. Neurochem. 116 , 1138-1147, (2011) The survival and death rates of inflammatory cells directly control their number and are substantially associated with the degree of inflammation. Microglia, key players in neuroinflammation, often cause excessive reactions implicated in neurological diseases... |
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Nucleotide-dependent shape changes in the reverse direction motor, myosin VI.
Biophys. J. 99 , 3336-3344, (2010) We have studied the shape of myosin VI, the actin minus-end directed motor, by negative stain and metal shadow electron microscopy. Single particle processing was used to make two-dimensional averages of the stain images, which greatly increases the clarity a... |
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Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A.
RNA 9(10) , 1180-7, (2003) Whereas ATPgammaS is often considered a nonhydrolyzable substrate for ATPases, we present evidence that ATPgammaS is a good substrate for the RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eIF4A. In the presence of saturating single-stra... |
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Goody, R. S., and Eckstein, F.
J. Am. Chem. Soc. 93 , 6252, (1971)
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