Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt
Modify Date: 2024-01-03 08:11:16
![Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt Structure](https://www.chemsrc.com/caspic/206/93839-89-5.png)
Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt structure
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Common Name | Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt | ||
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| CAS Number | 93839-89-5 | Molecular Weight | 546.979 | |
| Density | N/A | Boiling Point | 940.5ºC at 760 mmHg | |
| Molecular Formula | C10H12Li4N5O12P3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 522.6ºC | |
Use of Adenosine 5'-[γ-thio]triphosphate Tetralithium SaltATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1]. |
| Name | ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt |
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| Synonym | More Synonyms |
| Description | ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1]. |
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| Related Catalog | |
| In Vitro | ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3]. |
| In Vivo | ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3]. |
| References |
| Boiling Point | 940.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H12Li4N5O12P3S |
| Molecular Weight | 546.979 |
| Flash Point | 522.6ºC |
| Exact Mass | 547.005615 |
| PSA | 334.90000 |
| LogP | 1.47200 |
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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.
J. Mol. Biol. 426(15) , 2886-99, (2014) The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms ... |
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The enzymatic synthesis of thiophosphate analogs of nucleotides.
Biochim. Biophys. Acta 276 , 155, (1972)
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ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.
Cell 144 , 526-538, (2011) In the eukaryotic 26S proteasome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous ring complex, PAN. To clarify the role of ATP in proteolysis, we studied how... |
| Tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]adenosine |
| Adenosine, 5'-O-[hydroxy[[hydroxy[(hydroxymercaptophosphinyl)oxy]phosphinyl]oxy]phosphinyl]-, lithium salt (1:4) |