Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt

Names

[ Name ]:
Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt

[Synonym ]:
Tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]adenosine
Adenosine, 5'-O-[hydroxy[[hydroxy[(hydroxymercaptophosphinyl)oxy]phosphinyl]oxy]phosphinyl]-, lithium salt (1:4)

Biological Activity

[Description]:

ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

Research Areas >> Inflammation/Immunology

[In Vitro]

ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].

[In Vivo]

ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].

[References]

[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7.

[2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55.

[3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24.

Chemical & Physical Properties

[ Boiling Point ]:
940.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂Li₄N₅O₁₂P₃S

[ Molecular Weight ]:
546.979

[ Flash Point ]:
522.6ºC

[ Exact Mass ]:
547.005615

[ PSA ]:
334.90000

[ LogP ]:
1.47200

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

J. Mol. Biol. 426(15) , 2886-99, (2014)

The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms ...

The enzymatic synthesis of thiophosphate analogs of nucleotides.

Biochim. Biophys. Acta 276 , 155, (1972)

ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.

Cell 144 , 526-538, (2011)

In the eukaryotic 26S proteasome, the 20S particle is regulated by six AAA ATPase subunits and, in archaea, by a homologous ring complex, PAN. To clarify the role of ATP in proteolysis, we studied how...