盐酸美普他酚
盐酸美普他酚结构式
|
常用名 | 盐酸美普他酚 | 英文名 | Meptazinol HCl |
|---|---|---|---|---|
| CAS号 | 59263-76-2 | 分子量 | 269.810 | |
| 密度 | N/A | 沸点 | 354.8ºC at 760 mmHg | |
| 分子式 | C15H24ClNO | 熔点 | 250-252ºC | |
| MSDS | 中文版 美版 | 闪点 | 160.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.
Pharmacol. Biochem. Behav. 104 , 138-43, (2013) Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder which is characterized by the progressive deterioration of cognition and the emergence of behavioral and psychological symptoms in aging patients. Given that the clinical effectiveness of a... |
|
|
Reflex activity caused by laryngoscopy and intubation is obtunded differently by meptazinol, nalbuphine and fentanyl.
Eur. J. Anaesthesiol. 24(1) , 53-8, (2007) To evaluate the different potencies of several opioids in obtunding reflex mechanisms of laryngoscopy and intubation.Three groups of patients (each n = 25, ASA 1-2) undergoing elective plastic surgery were randomly given meptazinol (2.5 mg kg-1), nalbuphine (... |
|
|
Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol.
Neurosci. Lett. 329(1) , 25-8, (2002) Based on the recent finding that tramadol (TRAM) produces conditioned place preference (CPP) and dopamine release in the nucleus accumbens, it was suggested that the abuse liability of TRAM may be greater than hitherto assumed. We re-evaluated the effects of ... |
|
|
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.
Bioorg. Med. Chem. Lett. 15(22) , 4953-6, (2005) Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prod... |
|
|
Synthesis and relative bioavailability of meptazinol benzoyl esters as prodrugs.
Bioorg. Med. Chem. Lett. 15(10) , 2607-9, (2005) Three meptazinol benzoyl esters (1-3) were synthesized as prodrugs to minimize the first-pass effect of meptazinol and improve the bioavailability. Among these three esters, compound 3 showed better bioavailability than the parent meptazinol. Further, the rel... |
|
|
Protection of acetylcholinesterase by meptazinol in mice exposed to di-isopropyl fluorophosphate. Comparison with physostigmine.
J. Pharm. Pharmacol. 43(5) , 366-9, (1991) The protective action of meptazinol against acute di-isopropyl fluorophosphate (DFP) intoxication has been evaluated in mice by measuring the effects on the DFP LD50 of the pretreatment of the animals with increasing doses of the drug. Meptazinol at the doses... |
|
|
[Obstetric analgesia in German clinics. Remifentanil as alternative to regional analgesia].
Anaesthesist 60(11) , 995-1001, (2011) Epidural regional analgesia is still recommended as the gold standard for obstetric analgesia due to its high efficacy and less depressing effects to the central nervous system. However, if absolute or relative contraindications for a regional anesthetic tech... |
|
|
Opioid analgesics.
Br. J. Hosp. Med. 57(3) , 105-6, (1997) This article discusses recent developments in opioid pharmacology. Selective activity at different opioid receptors promises, but has not yet provided, a strong analgesic without opioid side-effects. The startling pharmacokinetic profile of the new esterase-m... |
|
|
Inhibitory effect of intrathecal meptazinol on carrageenan-induced thermal hyperalgesia in rats.
Neurosci. Lett. 356(1) , 9-12, (2004) The effect of meptazinol in the spinal cord on carrageenan-induced hyperalgesia was investigated. The latency of paw withdrawal (PWL) to a thermal stimulus was used as an index of inflammatory hyperalgesia in awake rats. Intrathecal (i.t.) injection of 10 and... |
|
|
[New opiates in anesthesiology-resuscitation].
Rev. Esp. Anestesiol. Reanim. 40(2) , 94-8, (1993)
|