Meptazinol HCl

Modify Date: 2024-01-14 08:53:38

Meptazinol HCl Structure
Meptazinol HCl structure
 Common Name Meptazinol HCl
CAS Number 59263-76-2 Molecular Weight 269.810
Density N/A Boiling Point 354.8ºC at 760 mmHg
Molecular Formula C15H24ClNO Melting Point 250-252ºC
MSDS Chinese USA Flash Point 160.6ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Meptazinol HCl


Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.

 Names

Name Meptazinol Hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 354.8ºC at 760 mmHg
Melting Point 250-252ºC
Molecular Formula C15H24ClNO
Molecular Weight 269.810
Flash Point 160.6ºC
Exact Mass 269.154633
PSA 23.47000
LogP 3.89560
Storage condition Desiccate at +4°C
Water Solubility H2O: >10mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL4250000
CHEMICAL NAME :
Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride
CAS REGISTRY NUMBER :
59263-76-2
LAST UPDATED :
199512
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C15-H23-N-O.Cl-H
MOLECULAR WEIGHT :
269.85
WISWESSER LINE NOTATION :
T7NTJ A1 C2 CR CQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
106 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
282 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4550 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
RTECS SL4250000
HS Code 2942000000

 Synthetic Route

3-ethylhexahydro-3-(3-methoxyphenyl)-1-methyl-1H-azepine structure

3-ethylhexahydr...

CAS#:71556-73-5

~91%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: Bradley; Cavalla; Edington; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
Caprolactam structure

Caprolactam

CAS#:105-60-2

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
1-Methylazepan-2-one structure

1-Methylazepan-2-one

CAS#:2556-73-2

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
2-Chloroanisole structure

2-Chloroanisole

CAS#:766-51-8

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
1-Methyl-3-(3-oxo-1-cyclohexen-1-yl)-2-azepanone structure

1-Methyl-3-(3-o...

CAS#:71556-70-2

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
3-(3-Hydroxyphenyl)-1-methyl-2-azepanone structure

3-(3-Hydroxyphe...

CAS#:71592-44-4

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one structure

hexahydro-3-(3-...

CAS#:71592-43-3

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
3-ethylhexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one structure

3-ethylhexahydr...

CAS#:71556-72-4

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385
Formaldehyde structure

Formaldehyde

CAS#:50-00-0
N-desmethylmeptazinol structure

N-desmethylmept...

CAS#:59263-75-1

~%

Meptazinol HCl Structure

Meptazinol HCl

CAS#:59263-76-2
Literature: European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385

 Customs

HS Code 2942000000

 Articles23

More Articles
Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.

Pharmacol. Biochem. Behav. 104 , 138-43, (2013)

Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder which is characterized by the progressive deterioration of cognition and the emergence of behavioral and psychological symptoms in...
Reflex activity caused by laryngoscopy and intubation is obtunded differently by meptazinol, nalbuphine and fentanyl.

Eur. J. Anaesthesiol. 24(1) , 53-8, (2007)

To evaluate the different potencies of several opioids in obtunding reflex mechanisms of laryngoscopy and intubation.Three groups of patients (each n = 25, ASA 1-2) undergoing elective plastic surgery...
Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol.

Neurosci. Lett. 329(1) , 25-8, (2002)

Based on the recent finding that tramadol (TRAM) produces conditioned place preference (CPP) and dopamine release in the nucleus accumbens, it was suggested that the abuse liability of TRAM may be gre...

 Synonyms

Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride (1:1)
3-(3-Ethyl-1-methylazepan-3-yl)phenol hydrochloride (1:1)
3-(3-ethyl-1-methylazepan-3-yl)phenol,hydrochloride
3-(3-Ethyl-1-methyl-3-azepanyl)phenol hydrochloride (1:1)
UNII:T62FQ4ZCPA
MEPTAZINOL HYDROCHLORIDE
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