85278-24-6
85278-24-6 structure
- Name: MDL72274 HCl
- Chemical Name: (E)-2-phenyl-3-chloroallylamine hydrochloride
- CAS Number: 85278-24-6
- Molecular Formula: C9H11Cl2N
- Molecular Weight: 204.09600
- Create Date: 2018-04-18 23:04:13
- Modify Date: 2025-11-03 16:23:28
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MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.
| Name | (E)-2-phenyl-3-chloroallylamine hydrochloride |
|---|---|
| Synonyms |
(E)-3-Chloro-2-phenyl-allylamine
hydrochloride (E)-3-chloro-2-phenylallylamine hydrochloride MDL72274 HCl |
| Molecular Formula | C9H11Cl2N |
|---|---|
| Molecular Weight | 204.09600 |
| Exact Mass | 203.02700 |
| PSA | 26.02000 |
| LogP | 3.72730 |