85278-24-6

85278-24-6结构式

常用中文名：MDL72274 HCl
常用英文名：MDL72274 HCl
CAS号：85278-24-6
分子式：C₉H₁₁Cl₂N
分子量：204.09600
发布时间：2018-04-18 23:04:13
更新时间：2024-04-06 16:25:19
MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.

英文名	(E)-2-phenyl-3-chloroallylamine hydrochloride
英文别名	(E)-3-Chloro-2-phenyl-allylamine hydrochloride (E)-3-chloro-2-phenylallylamine hydrochloride MDL72274 HCl