奎尼丁
奎尼丁结构式
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常用名 | 奎尼丁 | 英文名 | Quinidine |
|---|---|---|---|---|
| CAS号 | 56-54-2 | 分子量 | 324.417 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 495.9±40.0 °C at 760 mmHg | |
| 分子式 | C20H24N2O2 | 熔点 | 168-172 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 253.7±27.3 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.
Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 883-91, (2014) Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known wheth... |
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Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.
Xenobiotica 45(1) , 29-44, (2014) 1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes ... |
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Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.
Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014) In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active eff... |
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Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.
Environ. Toxicol. Pharmacol. 38(3) , 901-12, (2014) This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The i... |
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Phenotyping of CYP450 in human liver microsomes using the cocktail approach.
Anal. Bioanal. Chem 406(20) , 4875-87, (2014) The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-spe... |
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Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.
Drug Metab. Dispos. 42(12) , 2023-32, (2014) Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer's disease... |
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Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.
Toxicol. Lett. 230(1) , 28-35, (2014) Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhib... |
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A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.
Aquat. Toxicol. 159 , 127-37, (2015) The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that mimics the function of the tel... |
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Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors.
Pharm. Res. 31(12) , 3415-25, (2014) The membrane protein P-glycoprotein (P-gp) plays key roles in the oral bioavailability of drugs, their blood brain barrier passage as well as in multidrug resistance. For new drug candidates it is mandatory to study their interaction with P-gp, according to F... |
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Quantitation of pilsicainide in microscale samples of human biological fluids using liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 985 , 172-9, (2015) This paper describes a sensitive, reliable method to determine pilsicainide (PLC) levels in microscale sample volumes of human biological fluids using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization (ESI). PLC and quinid... |