盐酸古柯碱
一般危化品
盐酸古柯碱结构式
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常用名 | 盐酸古柯碱 | 英文名 | cocaine Hcl |
|---|---|---|---|---|
| CAS号 | 53-21-4 | 分子量 | 339.81400 | |
| 密度 | N/A | 沸点 | 395.2ºC at 760mmHg | |
| 分子式 | C17H22ClNO4 | 熔点 | 200-202ºC | |
| MSDS | 中文版 美版 | 闪点 | 192.8ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Alterations in brain neurotrophic and glial factors following early age chronic methylphenidate and cocaine administration.
Behav. Brain Res. 282 , 125-32, (2015) Attention deficit hyperactivity disorder (ADHD) overdiagnosis and a pharmacological attempt to increase cognitive performance, are the major causes for the frequent (ab)use of psychostimulants in non-ADHD individuals. Methylphenidate is a non-addictive psycho... |
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Sensitive and selective cocaine electrochemical detection using disposable sensors.
Anal. Chim. Acta 834 , 30-6, (2014) This paper describes the voltammetric determination of cocaine in presence of three different interferences that could be found in street samples using disposable sensors. The electrochemical analysis of this alkaloid can be affected by the presence of codein... |
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On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Psychopharmacol. Ser. 232(2) , 421-35, (2015) Several studies have suggested the inhibitory control of adenosine (A)2A receptor stimulation in cocaine-induced behavioral actions.A combination of systemic or local drug injections and in vivo neurochemical analysis investigated A2A receptors in cocaine and... |
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Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine.
Addict. Biol. 20(3) , 445-57, (2015) In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists ... |
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Effects of adolescent caffeine consumption on cocaine sensitivity.
Neuropsychopharmacology 40(4) , 813-21, (2015) Caffeine is the most commonly used psychoactive substance, and consumption by adolescents has risen markedly in recent years. We identified the effects of adolescent caffeine consumption on cocaine sensitivity and determined neurobiological changes within the... |
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Dopamine D1/D5 receptors in the dorsal hippocampus are required for the acquisition and expression of a single trial cocaine-associated memory.
Neurobiol. Learn. Mem. 116 , 172-80, (2014) The role of the hippocampus in memory supporting associative learning between contexts and unconditioned stimuli is well documented. Hippocampal dopamine neurotransmission modulates synaptic plasticity and memory processing of fear-motivated and spatial learn... |
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Determination of levamisole and tetramisole in seized cocaine samples by enantioselective high-performance liquid chromatography and circular dichroism detection.
J. Chromatogr. A. 1363 , 150-4, (2014) Levamisole, an anthelmintic drug, has been increasingly employed as an adulterant of illicit street cocaine over the last decade; recently, the use of tetramisole, the racemic mixture of levamisole and its enantiomer dexamisole, was also occasionally observed... |
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Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
Brain 137(Pt 8) , 2287-302, (2014) Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms of Parkinson's disease, but the causes for the high vulnerability of SN DA neurons, compa... |
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Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.
J. Neurosci. 33(19) , 8101-13, (2013) Homer postsynaptic scaffolding proteins regulate forebrain glutamate transmission and thus, are likely molecular candidates mediating hypofrontality in addiction. Protracted withdrawal from cocaine experience increases the relative expression of Homer2 versus... |
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Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.
Pharmacol. Biochem. Behav. 124 , 320-5, (2014) Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefor... |