NS1643
NS1643结构式
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常用名 | NS1643 | 英文名 | NS-1643 |
|---|---|---|---|---|
| CAS号 | 448895-37-2 | 分子量 | 380.24200 | |
| 密度 | 1.627g/cm3 | 沸点 | 342.311ºC at 760 mmHg | |
| 分子式 | C15H10F6N2O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 160.824ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
J. Pharmacol. Exp. Ther. , (2014) Human ether-a-go-go-related gene (hERG) and KCNQ channels are two classes of voltage-gated potassium channels. Specific mutations have been identified that are causal for type II long QT (LQT2) syndrome, neonatal epilepsy, and benign familial neonatal convuls... |
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Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
J. Neurosci. 36 , 2769-81, (2016) DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal link between TET dysregulation and nociceptive modulation has not been established.... |
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Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.
Cell Death Dis. 4 , e652, (2013) Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian cells including cardiac myocytes. hERG1 has recently been found to be expressed in non-excitable cancer cells of different histog... |