NS-1643
NS-1643 structure
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Common Name | NS-1643 | ||
|---|---|---|---|---|
| CAS Number | 448895-37-2 | Molecular Weight | 380.24200 | |
| Density | 1.627g/cm3 | Boiling Point | 342.311ºC at 760 mmHg | |
| Molecular Formula | C15H10F6N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 160.824ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
J. Pharmacol. Exp. Ther. , (2014) Human ether-a-go-go-related gene (hERG) and KCNQ channels are two classes of voltage-gated potassium channels. Specific mutations have been identified that are causal for type II long QT (LQT2) syndrome, neonatal epilepsy, and benign familial neonatal convuls... |
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Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
J. Neurosci. 36 , 2769-81, (2016) DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal link between TET dysregulation and nociceptive modulation has not been established.... |
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Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.
Cell Death Dis. 4 , e652, (2013) Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian cells including cardiac myocytes. hERG1 has recently been found to be expressed in non-excitable cancer cells of different histog... |