![]() [5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸结构式
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常用名 | [5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸 | 英文名 | Leukotriene B4 |
---|---|---|---|---|
CAS号 | 71160-24-2 | 分子量 | 336.466 | |
密度 | 1.0±0.1 g/cm3 | 沸点 | 536.4±50.0 °C at 760 mmHg | |
分子式 | C20H32O4 | 熔点 | -144.0 °C (lit.) | |
MSDS | 美版 | 闪点 | 292.3±26.6 °C | |
符号 |
![]() ![]() GHS02, GHS07 |
信号词 | Danger |
HMDB: a knowledgebase for the human metabolome.
Nucleic Acids Res. 37(Database issue) , D603-10, (2009) The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Si... |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite ref... |
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Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
Antimicrob. Agents Chemother. 58(8) , 4298-307, (2014) The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B4 (LTB4), is a classic marker of inflammatory disease. The clearance of apoptotic neutrophils, inhibition of proinflammatory signaling, and production of proresolving lipids (... |
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Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.
Br. J. Pharmacol. 172(3) , 910-23, (2015) Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n-3 or n-6 p... |
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In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse.
PLoS ONE 10 , e0143141, (2015) The activation and infiltration of polymorphonuclear neutrophils (PMN) are critical key steps in inflammation. PMN-mediated inflammation is limited by anti-inflammatory and pro-resolving mechanisms, including specialized pro-resolving lipid mediators (SPM). W... |
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The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.
Dis. Model Mech. 8(3) , 253-69, (2015) The recruitment of leukocytes to infectious foci depends strongly on the local release of chemoattractant mediators. The human CXC chemokine receptor 3 (CXCR3) is an important node in the chemokine signaling network and is expressed by multiple leukocyte line... |
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13,14-Dihydroxy groups are critical for the anti-cancer effects of garcinol.
Bioorg. Chem. 60 , 123-9, (2015) In the presence of K2CO3/Cs2CO3 (molar ratio 10:1), garcinol was subjected to methylation by reaction with iodomethane at room temperature to afford 13,14-dimethoxy garcinol. The methylated garcinol derivative was screened against oral cancer cell line SCC15 ... |
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Lipidomics reveals a remarkable diversity of lipids in human plasma.
J. Lipid Res. 51(11) , 3299-305, (2010) The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians r... |
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Significance of fatty acids in pregnancy-induced immunosuppression.
Clin. Diagn. Lab. Immunol. 6(4) , 587-93, (1999) Pregnancy can exert suppressive effects on chronic inflammatory conditions. We have previously demonstrated a depression in polymorphonuclear leukocyte (PMN) respiratory burst during pregnancy which could explain this amelioration. To elucidate the biochemica... |
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Effect of allergen sensitization on external root resorption.
J. Dent. Res. 92(7) , 641-7, (2013) In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic dise... |