苦豆碱
苦豆碱结构式
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常用名 | 苦豆碱 | 英文名 | Aloperine |
|---|---|---|---|---|
| CAS号 | 56293-29-9 | 分子量 | 232.365 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 367.7±37.0 °C at 760 mmHg | |
| 分子式 | C15H24N2 | 熔点 | 69 - 71ºC | |
| MSDS | 中文版 美版 | 闪点 | 155.8±17.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.
PLoS ONE 11 , e0149618, (2016) Porphyromonas gingivalis is a keystone pathogen of periodontitis. One of its bacterial characteristics is the ability to invade various host cells, including nonphagocytic epithelial cells and fibroblasts, which is known to facilitate P. gingivalis adaptation... |
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Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms.
J. Hematol. Oncol. 8 , 26, (2015) Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine significantly induced apoptosis in colon cancer SW480 and HCT11... |
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[Simultaneous determination of 7 alkaloid in herba Sophorae Alopecuroidis by HPLC].
Zhongguo Zhong Yao Za Zhi 36(11) , 1483-6, (2011) To establish a method for determination of 7 alkaloid in Herba Sophorae Alopecuroidis by HPLC.X-Brige C18 (4.6 mm x 200 mm, 5 microm) column was used with acetonitriles-0.05 mol x L(-1) KH2PO4 solution (2.0 mL x L(-1) triethylamine) with gradient elution as t... |
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[Constituents in the alkaloid fraction of Kushen decoction].
Zhongguo Zhong Yao Za Zhi 31(7) , 557-60, (2006) To study the chemical constituents of the alkaloid fraction of Kushen decoction.Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods.Eight compounds were isolated and identified as m... |
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Concise total synthesis of (+/-)-aloperine and 6-epi-aloperine.
Org. Lett. 4(17) , 2925-8, (2002) [reaction: see text] Total synthesis of aloperine and 6-epi-aloperine is reported. The crucial steps of the synthetic strategy are an aza-annulation reaction and an intermolecular Diels-Alder reaction. The synthetic plan proceeds from commercially available p... |
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Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.
Eur. J. Pharmacol. 629(1-3) , 147-52, (2010) Allergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response. Multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. Alo... |
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In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait.
Basic Clin Pharmacol Toxicol. 108(5) , 304-9, (2011) The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characteri... |
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Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.
Eur. J. Pharmacol. 658(2-3) , 263-9, (2011) Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. N... |
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Relative and absolute configuration of aloperine.
Acta Crystallogr. C 53 ( Pt 10) , 1510-2, (1997) The relative and absolute configuration of the title compound, (6R,7R,9R,11S)-16,17-didehydro-9-de-2-piperidinylormosanine, C15H24N2, has been elucidated. Two X-ray structures, one of the free base of the alkaloid and the second of its dihydrochloride monohyd... |
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Synthesis of an optically pure synthetic intermediate of aloperine from a yeast-reductive product.
Biosci. Biotechnol. Biochem. 69(8) , 1589-94, (2005) Optically pure (S)- and (R)-vinylpiperidine 2 and (S)- and (R)-(hydroxyethyl)piperidine 3, which were key intermediates for the synthesis of aloperine, were synthesized from yeast-reductive products. |