4,6-二氧代庚酸
4,6-二氧代庚酸结构式
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常用名 | 4,6-二氧代庚酸 | 英文名 | 4,6-Dioxoheptanoic acid |
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| CAS号 | 51568-18-4 | 分子量 | 158.15200 | |
| 密度 | 1.189 g/cm3 | 沸点 | 318.7ºC at 760 mmHg | |
| 分子式 | C7H10O4 | 熔点 | 66-67ºC | |
| MSDS | 中文版 美版 | 闪点 | 160.8ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.
Haematologica 100 , 720-9, (2015) Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Here, we investigated the role of the two Flvcr1 isoforms during erythropoiesis. We... |
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Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
J. Immunol. 195 , 2763-73, (2015) Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the implications for TB diagnosis and disease staging are poorly ... |
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Single dose NTBC-treatment of hereditary tyrosinemia type I.
J. Inherit. Metab. Dis. 35(5) , 831-6, (2012) NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3cyclohexanedione) is the mainstay of treatment in tyrosinemia type 1 (HT 1). The current recommendation is to divide the total daily dose of NTBC into two doses. We monitored the plasma NTBC concentrations in a se... |
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LC-MS/MS method for simultaneous determination on a dried blood spot of multiple analytes relevant for treatment monitoring in patients with tyrosinemia type I.
Anal. Chem. 84(2) , 1184-8, (2012) Tyrosinemia type 1 is caused by deficiency of fumarylacetoacetate hydrolase. The enzymatic defect impairs the conversion of fumarylacetoacetate to fumarate, causing accumulation of succinylacetone which induces severe liver and kidney dysfunction along with m... |
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Clinical, biochemical, and genetic analysis of a Korean neonate with hereditary tyrosinemia type 1.
Clin. Chem. Lab Med. 47(8) , 930-3, (2009) Hereditary tyrosinemia type 1 (HT1; MIM 276700) is caused by mutations in the fumarylaceto-acetate hydrolase (FAH) gene, and is the most severe disorder associated with the tyrosine catabolic pathway. HT1 is a very rare disorder and no genetically confirmed c... |
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The stability of markers in dried-blood spots for recommended newborn screening disorders in the United States.
Clin. Biochem. 44(17-18) , 1445-50, (2011) We aimed to measure separately the contributions of heat and humidity to changes in levels of 34 markers of inborn disorders in dried-blood-spot (DBS) samples.We stored paired sets of DBSs at 37°C for predetermined intervals in low-humidity and high-humidity ... |
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Analysis of succinylacetone, as a Girard T derivative, in urine and dried bloodspots by flow injection electrospray ionization tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 21(1) , 59-63, (2007) Flow injection electrospray ionization tandem mass spectrometric methods for succinylacetone (SA) in 250 microL urine, using d5-SA as internal standard, and in 3 mm dried bloodspots, using 13C4-SA as internal standard, are described. Selectivity and sensitivi... |
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Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways.
Biochem. Biophys. Res. Commun. 401(1) , 32-6, (2010) Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified co... |
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High-resolution metabolomics to discover potential parasite-specific biomarkers in a Plasmodium falciparum erythrocytic stage culture system.
Malaria Journal 14 , 122, (2015) Current available malaria diagnostic methods each have some limitations to meet the need for real-time and large-scale screening of asymptomatic and low density malaria infection at community level. It was proposed that malaria parasite-specific low molecular... |
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Solution structure of succinylacetone, an unsymmetrical beta-diketone, as studied by 13C NMR and GIAO-DFT calculations.
J. Org. Chem. 74(22) , 8604-9, (2009) The enolization degrees of succinylacetone, an important heme biosynthesis inhibitor, have been determined in CDCl(3) and water solutions using (1)H NMR. The solution structures of SA have been investigated using a combined NMR/theoretical [GIAO DFT PBE1PBE/6... |