氟硅唑
氟硅唑结构式
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常用名 | 氟硅唑 | 英文名 | Flusilazole |
|---|---|---|---|---|
| CAS号 | 85509-19-9 | 分子量 | 315.393 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 392.5±52.0 °C at 760 mmHg | |
| 分子式 | C16H15F2N3Si | 熔点 | 51-53ºC | |
| MSDS | 中文版 美版 | 闪点 | 191.2±30.7 °C | |
| 符号 |
GHS07, GHS08, GHS09 |
信号词 | Danger |
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Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry.
Anal. Bioanal. Chem 402(8) , 2555-64, (2012) The liquid chromatography-mass spectrometry (LC-MS) analysis of complex samples such as biological fluid extracts is widespread when searching for new biomarkers as in metabolomics. The success of this hyphenation resides in the orthogonality of both separati... |
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Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.).
Commun. Agric. Appl. Biol. Sci. 71(3 Pt B) , 1041-8, (2006) The present work aimed at the study of the effects of Artea and Punch; two systemic fungicides on durum Wheat (Triticum durum L. cv. GTA dur). Seeds were grown in a medium containing respectively 25, 50, 75 and 100 ppm of Artea and Punch under controlled cond... |
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Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.
Toxicol. Sci. 127(1) , 303-12, (2012) The zebrafish embryotoxicity test (ZET) is considered a promising alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. However, implementation of transcriptomics may help to detect m... |
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Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.
Toxicol. Appl. Pharmacol. 251(2) , 110-8, (2011) The murine embryonic stem cell test (EST) is designed to evaluate developmental toxicity based on compound-induced inhibition of embryonic stem cell (ESC) differentiation into cardiomyocytes. The addition of transcriptomic evaluation within the EST may result... |
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Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).
Toxicol. Appl. Pharmacol. 262(3) , 330-40, (2012) Alternative assays for developmental toxicity testing are needed to reduce animal use in regulatory toxicology. The in vitro murine neural embryonic stem cell test (ESTn) was designed as an alternative for neurodevelopmental toxicity testing. The integration ... |
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Integrated palladium-catalyzed arylation of heavier Group 14 hydrides.
Chemistry 16(45) , 13519-27, (2010) A convenient procedure has been developed for the preparation of Group 14 compounds by integrated palladium-catalyzed cross-coupling of aromatic iodides with the corresponding Group 14 hydrides in the presence of a base. The reaction conditions can be applied... |
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Antifungal triazoles induce malformations in vitro.
Reprod. Toxicol. 15(4) , 421-7, (2001) Triazole-derivatives are antimycotics used in agriculture as well as in clinical and veterinary therapy. The aim of the present work is the in vitro comparative study of the teratogenic activity of triazole (the parental compound), flusilazole (an agricultura... |
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Comparative effects of the azole-based fungicide flusilazole on yeast and mammalian lanosterol 14 alpha-methyl demethylase.
Antimicrob. Agents Chemother. 33(8) , 1228-31, (1989) Flusilazole inhibits the 14 alpha-demethylation of [24,25-3H-2]dihydrolanosterol by yeast and rat liver cell-free preparations. The 50% inhibitory concentration of demethylation shows that the yeast system is 100 times more sensitive than the rat system. Puri... |
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Functional expression of Saccharomyces cerevisiae CYP51A1 encoding lanosterol-14-demethylase in tobacco results in bypass of endogenous sterol biosynthetic pathway and resistance to an obtusifoliol-14-demethylase herbicide inhibitor.
Plant J. 7(5) , 761-70, (1995) Nicotiana tabacum protoplasts have been transformed by Agrobacterium tumefaciens containing a T-DNA in which the gene CYP51A1 encoding lanosterol-14-demethylase (LAN14DM) from Saccharomyces cerevisiae is under the control of a cauliflower mosaic virus (CaMV) ... |
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Metabolism of [(14)C]flusilazole in the goat.
J. Agric. Food Chem. 47(6) , 2439-46, (1999) [Phenyl(U)-(14)C] and [triazole(3)-(14)C]flusilazole ([(bis 4-fluorophenyl)]methyl(1H-1,2,4-triazole-1-ylmethyl)silane; I) were extensively metabolized when fed to lactating goats (Capra hircus). The primary metabolites identified in goat tissues and milk wer... |