5-(N,N-六亚甲基)阿米洛利
5-(N,N-六亚甲基)阿米洛利结构式
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常用名 | 5-(N,N-六亚甲基)阿米洛利 | 英文名 | 5-(N,N-Hexamethylene)-amiloride |
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| CAS号 | 1428-95-1 | 分子量 | 311.77100 | |
| 密度 | 1.63g/cm3 | 沸点 | 638.2ºC at 760mmHg | |
| 分子式 | C12H18ClN7O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 339.8ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Gossypetin ameliorates ionizing radiation-induced oxidative stress in mice liver--a molecular approach.
Free Radic. Res. 49 , 1173-86, (2015) Radioprotective action of gossypetin (GTIN) against gamma (γ)-radiation-induced oxidative stress in liver was explored in the present article. Our main aim was to evaluate the protective efficacy of GTIN against radiation-induced alteration of liver in murine... |
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Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II.
Arch. Virol. 160(5) , 1163-70, (2015) Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses encodes a hydrophobic transmembrane protein, the envelope ... |
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Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers.
Colloids Surf. B Biointerfaces 133 , 148-55, (2015) Electrospun nanofibers with antibacterial activity are greatly promising for medical treatment and water purification. Herein we report antibacterial nanofibers electrospun from a series of poly(dimethylamino ethyl methacrylate-co-alkyl methacrylates) (poly(D... |
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The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells.
Oncotarget 6(2) , 1262-75, (2015) Dysregulation of Na⁺/H⁺ exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumorigenesis and metastasis, the leading cause of patient mortality. The acidic tumor microenvironment is thought to facilitate the development of resistance to c... |
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Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans.
Drug Metab. Dispos. 43 , 1864-71, (2015) Generally, pharmacokinetic studies on 3,4-methylenedioxymethamphetamine (MDMA) in blood have been performed after conjugate cleavage, without taking into account that phase II metabolites represent distinct chemical entities with their own effects and stereos... |
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Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells.
Biochem. Biophys. Res. Commun. 455(3-4) , 363-70, (2014) We aimed to elucidate the effect of herbimycin A (HMA), a heat shock protein 90 inhibitor, on cell growth and epithelial-mesenchymal transition (EMT) in anaplastic thyroid carcinoma (ATC) cells. HMA inhibited cell growth and migration concomitantly with incre... |
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Sodium ion binding pocket mutations and adenosine A2A receptor function.
Mol. Pharmacol. 87(2) , 305-13, (2015) Recently we identified a sodium ion binding pocket in a high-resolution structure of the human adenosine A2A receptor. In the present study we explored this binding site through site-directed mutagenesis and molecular dynamics simulations. Amino acids in the ... |
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Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.
PLoS ONE 7(12) , e51451, (2012) Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers (NHEs) modulate the pHi, with NHE1 playing significant role... |
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Biomimetic DNA nanoballs for oligonucleotide delivery.
Biomaterials 62 , 155-63, (2015) Here, we designed biomimetic DNA nanoballs for delivery of multiple antisense oligonucleotides (ASOs). DNA templates with ASOs-complementary sequences were amplified by rolling circle amplification (RCA). RCA products were loaded with two types of ASOs by hyb... |
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The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.
J. Cell. Mol. Med. 19 , 1646-55, (2015) Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspa... |