环氧丙酰胺
环氧丙酰胺结构式
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常用名 | 环氧丙酰胺 | 英文名 | UNII:6G5ELX5XYN |
|---|---|---|---|---|
| CAS号 | 5694-00-8 | 分子量 | 87.077 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 321.9±31.0 °C at 760 mmHg | |
| 分子式 | C3H5NO2 | 熔点 | 32-34ºC | |
| MSDS | 中文版 美版 | 闪点 | 240.8±21.2 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.
PLoS ONE 9(5) , e94904, (2014) Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been assoc... |
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Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide.
Arch. Toxicol. 85(6) , 601-6, (2011) A dose of 0.99 mg d(3)-acrylamide (d(3)-AA) (13.2 μg/kg body weight) was ingested by a healthy male volunteer. Urine samples were collected over a period of 46 h after the intake and analyzed for the hydrolysis product of glycidamide (GA), 2,3-dihydroxy-propi... |
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Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide.
Mutat. Res. 752(1-2) , 1-7, (2013) Acrylamide (AA) is a probable human carcinogen generated in carbohydrate-rich foodstuffs upon heating. Glycidamide (GA), formed via epoxidation, presumably mediated by cytochrome P450 2E1, is considered to be the active metabolite that plays a central role in... |
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Dose dependent molecular effects of acrylamide and glycidamide in human cancer cell lines and human primary hepatocytes.
Toxicol. Lett. 217(2) , 111-20, (2013) Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms a... |
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Among 10 sociodemographic and lifestyle variables, smoking is strongly associated with biomarkers of acrylamide exposure in a representative sample of the U.S. Population.
J. Nutr. 143(6) , 995S-1000S, (2013) Hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) have been measured as biomarkers of acrylamide exposure and metabolism in a nationally representative sample of the U.S. population in the NHANES 2003-2004. We assessed the association of sociodem... |
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Acrylamide in health and disease.
Front. Biosci. (Schol. Ed.) 3 , 41-51, (2011) Acrylamide has been classified as a probable carcinogen and can be ingested, inhaled (e.g. tobacco smoke), or absorbed. Fried, starchy foods are the most prominent sources of exposure. The reaction between asparagine and fructose typically produces the most a... |
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Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women.
Br. J. Nutr. 105(9) , 1381-7, (2011) Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA... |
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Biological effects of acrylamide after daily ingestion of various foods in comparison to water: a study in rats.
Mol. Nutr. Food. Res. 55(3) , 387-99, (2011) Acrylamide (AA), classified as a genotoxic carcinogen, is generated by heating foods. We studied whether the food matrix modulates bioavailability and/or biotransformation and investigated kinetics and biological effectiveness of AA in rats.AA was given to th... |
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Mutagenicity of acrylamide and glycidamide in the testes of big blue mice.
Toxicol. Sci. 117(1) , 72-80, (2010) Acrylamide (AA) is an industrial chemical, a by-product of fried starchy foods, and a mutagen and rodent carcinogen. It can also cause damage during spermatogenesis. In this study, we investigated whether AA and its metabolite glycidamide (GA) induce mutageni... |
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Preconceptional paternal glycidamide exposure affects embryonic gene expression: single embryo gene expression study following in vitro fertilization.
Reprod. Toxicol. 32(4) , 463-71, (2011) Recognition of early determinants of disease onset has sparked an interest in paternally transmitted factors and their impact on the developing embryo. Acrylamide (AA), a widely distributed xenobiotic compound, is converted to its active metabolite glycidamid... |