β-富纳曲胺盐酸盐
β-富纳曲胺盐酸盐结构式
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常用名 | β-富纳曲胺盐酸盐 | 英文名 | β-Funaltrexamine hydrochloride,(E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacidmethylesterhydrochloride |
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| CAS号 | 72786-10-8 | 分子量 | 490.97600 | |
| 密度 | N/A | 沸点 | 695.2ºC at 760 mmHg | |
| 分子式 | C25H31ClN2O6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 374.2ºC |
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Novel orally available salvinorin A analog PR-38 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome.
J. Pharmacol. Exp. Ther. 350(1) , 69-78, (2014) The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal ... |
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Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
J. Pharmacol. Exp. Ther. 282 , 676, (1997) Activation of kappa receptors inhibits adenylate cyclase, enhances K+ conductance and reduces Ca++ conductance via pertussis toxin-sensitive G proteins. We recently cloned a human kappa opioid receptor and stably expressed it in Chinese hamster ovary (CHO) ce... |
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Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats.
Neuroscience 171(1) , 134-43, (2010) Hippocampus is a critical structure for the acquisition of morphine-induced conditioned place preference (CPP), which is a usual learning paradigm for assessing drug reward. However, the precise mechanisms remain largely unknown. Phosphatidylinositol 3-kinase... |
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The mu-opioid receptor-selective peptide antagonists, antanal-1 and antanal-2, produce anticonvulsant effects in mice.
Prog. Neuropsychopharmacol. Biol. Psychiatry 40 , 126-31, (2013) The activation of the mu-opioid receptors (MOR) in the central nervous system has a proconvulsant effect and seizures are a common side effect of high doses of short acting opioids, like morphine or fentanyl. However, the correct assessment of the role of MOR... |
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The involvement of micro-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice.
Int. Arch. Allergy Immunol. 152(4) , 342-52, (2010) Psychological stress has a recognized association with asthma symptoms. However, the mechanisms linking stress to the exacerbation of asthma are not well defined. mu-Opioid receptors (MOR) have been shown to be involved in the shift of the immune system towar... |
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Understanding the effect of different assay formats on agonist parameters: a study using the µ-opioid receptor.
J. Biomol. Screen. 16(7) , 706-16, (2011) The correct interpretation of data is fundamental to the study of G-protein-coupled receptor pharmacology. Often, new assay technologies are assimilated into the drug discovery environment without full consideration of the data generated. In this study, the a... |
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Induction of conditioned place preference and dopamine release by salsolinol in posterior VTA of rats: involvement of μ-opioid receptors.
Neurochem. Int. 59(5) , 559-62, (2011) Salsolinol (Sal), locally administered into the posterior VTA (pVTA) of rats, produces psychomotor responses and reinforcing effects, probably, through the activation of μ-opioid receptors (MORs). The neurochemical correlates of these phenomena are, however, ... |
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Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model.
Peptides 37(1) , 165-70, (2012) Apelin, as the endogenous ligand of the APJ receptor, is a novel identified neuropeptide whose biological functions are not fully understood. APJ receptor mRNA was found in several brain regions related to descending control system of pain, such as amygdala, ... |
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Central administration of neuronostatin induces antinociception in mice.
Peptides 32(9) , 1893-901, (2011) Neuronostatin, a recently discovered endogenous bioactive peptide, was encoded by pro-mRNA of somatostatin that contributes to modulation of nociception. However, nociceptive effect of neuronostatin is still not fully known. The aim of this study was to evalu... |
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Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
Brain Res. 1320 , 16-21, (2010) The central nucleus of amygdala (CeA) is a very important brain structure involved in multiple physiological functions, especially in pain modulation. There are high densities of galanin and galanin receptors found in the CeA. The present study was performed ... |