血管紧张素II
血管紧张素II结构式
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常用名 | 血管紧张素II | 英文名 | Angiotensin II acetate salt |
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| CAS号 | 4474-91-3 | 分子量 | 1046.179 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 809.08°C (rough estimate) | |
| 分子式 | C50H71N13O12 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats.
Can. J. Cardiol. 30(12) , 1700-5, (2014) Recent evidence suggests that an elevated plasma trimethylamine N-oxide (TMAO) level is associated with an increased risk of adverse cardiovascular events in humans; however, the mechanism is not clear. The aims of this study were to establish the plasma TMAO... |
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.
J. Cereb. Blood Flow Metab. 34(12) , 1887-97, (2014) Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the importance of the age-related decline in circulating insulin-... |
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Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.
Clin. Sci. 127(1) , 57-63, (2014) The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by the C-domain) and bradykinin (cleaved equally efficiently by ... |
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Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression.
Endocrinology 155(7) , 2524-33, (2014) Aldosterone synthesis is initiated upon the transport of cholesterol from the outer to the inner mitochondrial membrane, where the cholesterol is hydrolyzed to pregnenolone. This process is the rate-limiting step in acute aldosterone production and is mediate... |
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Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
Am. J. Physiol. Renal Physiol. 307(12) , F1355-62, (2014) Recent findings suggest the therapeutic action of relaxin during hypertension is dependent on nitric oxide synthase (NOS) activation; however, the mechanisms underlying the beneficial effects of relaxin on the NOS system have not been fully elucidated. We hyp... |
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Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.
Hypertension 65(2) , 352-61, (2015) We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and the development of deoxycorticosterone acetate (DOCA)-salt hypertension. Here, we designed and developed an antagonistic ... |
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Actin dynamics is rapidly regulated by the PTEN and PIP2 signaling pathways leading to myocyte hypertrophy.
Am. J. Physiol. Heart Circ. Physiol. 307(11) , H1618-25, (2014) Mature cardiac myocytes are terminally differentiated, and the heart has limited capacity to replace lost myocytes. Thus adaptation of myocyte size plays an important role in the determination of cardiac function. The hypothesis tested is that regulation of t... |
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Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(12) , R1396-404, (2014) Previous studies show that the angiotensin type 1 receptor (AT1R) is susceptible to rapid desensitization, but that more chronic treatments that stimulate ANG II lead to sensitization of several responses. It is unclear, however, if the processes of desensiti... |
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The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
J. Pharmacol. Exp. Ther. 351(2) , 390-402, (2014) A subset of angiotensin IV (AngIV)-related molecules are known to possess procognitive/antidementia properties and have been considered as templates for potential therapeutics. However, this potential has not been realized because of two factors: 1) a lack of... |
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Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.
Am. J. Physiol. Heart Circ. Physiol. 307(11) , H1559-64, (2014) Rupture of abdominal aortic aneurysm (AAA) is unpredictable and lethal. A clinically valid biomarker to monitor the disease has not been available. Based on our recent discoveries that uncoupled endothelial nitric oxide synthase (eNOS)/tetrahydrobiopterin def... |