Angiotensin II acetate salt

Modify Date: 2024-01-02 03:32:14

Angiotensin II acetate salt structure	Common Name	Angiotensin II acetate salt
	CAS Number	4474-91-3	Molecular Weight	1046.179
	Density	1.4±0.1 g/cm3	Boiling Point	809.08°C (rough estimate)
	Molecular Formula	C₅₀H₇₁N₁₃O₁₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Angiotensin II acetate salt

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

Name	Angiotensin Ⅱ, human
Synonym	More Synonyms

Description	Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease Natural Products >> Others Peptides Peptides
Target	Angiotensin receptor (AT receptor)[1]
In Vitro	Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].
In Vivo	To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].
Animal Admin	Mice[3] (129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes.
References	[1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. [2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24. [3]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.

Density	1.4±0.1 g/cm3
Boiling Point	809.08°C (rough estimate)
Molecular Formula	C₅₀H₇₁N₁₃O₁₂
Molecular Weight	1046.179
Exact Mass	1045.534546
PSA	406.34000
LogP	2.34
Index of Refraction	1.664
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW2165000

CHEMICAL NAME :: Angiotensin II, 5-L-isoleucine-

CAS REGISTRY NUMBER :: 4474-91-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C50-H71-N13-O12

MOLECULAR WEIGHT :: 1046.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6079,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 119 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,6109,1990

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BW2165000

Angiotensin Itr...

CAS#:484-42-4

Angiotensin II ...

CAS#:4474-91-3

H-His-Leu-OH

CAS#:7763-65-7

Literature: Kizuki; Moriya Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 9 p. 2721 - 2724

Boc-L-Proline

CAS#:15761-39-4

Boc-L-Isoleucine

CAS#:13139-16-7

Boc-L-phenylalanine

CAS#:13734-34-4

Boc-His(Tos)-OH.DCHA

CAS#:65057-34-3

Detail

Literature: Jubilut, Guita N.; Miranda, Maria Teresa; Tominaga, Mineko; Okada, Yoshio; Miranda, Antonio; Nakaie, Clovis R. Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1560 - 1563

Precursor 5
CAS#:484-42-4 Angiotensin Itr... CAS#:15761-39-4 Boc-L-Proline CAS#:13139-16-7 Boc-L-Isoleucine CAS#:13734-34-4 Boc-L-phenylalanine
CAS#:65057-34-3 Boc-His(Tos)-OH.DCHA
DownStream 2
CAS#:63-91-2 L-Phenylalanine CAS#:51833-78-4 Angiotensin I/I...

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Phenylalanine, α-aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolyl-

α-Aspartylarginylvalyltyrosylisoleucylhistidylprolylphenylalanine

phenylalanine, α-aspartylarginylvalyltyrosylisoleucylhistidylprolyl-

α-aspartyl-N-(diaminomethylidene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine

α-Aspartyl-N-(diaminomethylene)ornithylvalyltyrosylisoleucylhistidylprolylphenylalanine

Angiotensin II

ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE

Angiotensin II human

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Angiotensin II acetate salt
Price: ￥908.0/10mg ￥538.0/5mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Angiotensin II human
Price: $350.0/100mg $700.0/250mg $1400.0/1g
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: ANGIOTENSIN II, HUMAN
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4474-91-3 ANGIOTENSIN II, HUMAN
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Angiotensin II acetate salt

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