68521-88-0

68521-88-0 structure

Name: Angiotensin II human acetate
Chemical Name: Angiotensin II
CAS Number: 68521-88-0
Molecular Formula: C₅₂H₇₅N₁₃O₁₄
Molecular Weight: 1106.23000
Catalog: Biochemical Peptide
Create Date: 2018-04-02 08:00:00
Modify Date: 2024-01-03 18:03:31
Angiotensin II human acetate (Angiotensin II acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis[1][2].

Name	Angiotensin II
Synonyms	ANGIOTENSIN II ACETATE HUMAN ANGIOTENSIN II HUMAN ACETATE SALT EINECS 206-182-3 Human angiotensin II acetate salt ANGIOTENSIN,HUMAN angiotensin ii human acetate ANGIOTENSIN II ACETATE SALT ANGIOTENSIN II,MASS SPEC STANDARD HYPERTENSIN II ANGIOTENSIN II,HUMAN,SYNTHETIC Angiotensin II human

Description	Angiotensin II human acetate (Angiotensin II acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function[1]. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2]. At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT1 and AT2). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors[3].
In Vivo	To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[3].
References	[1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. [2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24. [3]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.

Molecular Formula	C₅₂H₇₅N₁₃O₁₄
Molecular Weight	1106.23000
Exact Mass	1105.56000
PSA	443.64000
LogP	3.16040
Appearance	powder \| orange
Storage condition	−20°C
Water Solubility	H2O: 25 mg/mL, clear, colorless

Hazard Codes	Xi
WGK Germany	3

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