Resin Selection Based on the Lability of Peptidyl-Resin Linkage towards HF and TFA Steps: Dependence on the C-Terminal Amino Acid and Peptide Length.

…, M Tominaga, Y OKADA, A MIRANDA…

Index: Jubilut, Guita N.; Miranda, Maria Teresa; Tominaga, Mineko; Okada, Yoshio; Miranda, Antonio; Nakaie, Clovis R. Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1560 - 1563

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Citation Number: 7

Abstract

Ideally, the solid support used for tert-butyloxycarbonyl (Boc)-peptide synthesis method must allow sufficient stability of the peptide linkage towards TFA-α-amino deprotection but adequate lability to final HF cleavage. Due to these conflicting characteristics, the choice of the correct resin for peptide synthesis is complex and dependent upon many factors. Aiming to clarify this issue, a time-course study of the trifluoroacetic acid (TFA) and HF steps using ...