L-Phenylalanine structure
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Common Name | L-Phenylalanine | ||
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CAS Number | 63-91-2 | Molecular Weight | 165.189 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 307.5±30.0 °C at 760 mmHg | |
Molecular Formula | C9H11NO2 | Melting Point | 270-275ºC (dec.)(lit.) | |
MSDS | USA | Flash Point | 139.8±24.6 °C |
Use of L-PhenylalanineL-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1]Target: Calcium ChannelL-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3]. |
Name | L-phenylalanine |
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Synonym | More Synonyms |
Description | L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM [1]Target: Calcium ChannelL-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression [4] which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria [5]. L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect [3]. |
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Related Catalog | |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 307.5±30.0 °C at 760 mmHg |
Melting Point | 270-275ºC (dec.)(lit.) |
Molecular Formula | C9H11NO2 |
Molecular Weight | 165.189 |
Flash Point | 139.8±24.6 °C |
Exact Mass | 165.078979 |
PSA | 63.32000 |
LogP | 1.11 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.576 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | C: Corrosive; |
Risk Phrases | R36/37/38 |
Safety Phrases | 22-24/25-37/39-45-36/37/39-27-26 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | AY7535000 |
HS Code | 29224995 |
Precursor 6 | |
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DownStream 10 | |
HS Code | 29224995 |
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Benzenepropanethioic acid,S-phenyl ester |
(S)-phenylalanine |
L-Phenylalanine |
EINECS 200-568-1 |
(2S)-2-amino-3-phenylpropanoic acid |
L-PHENYLALININE |
α-Amino-β-phenylpropionic acid, L- |
H-Phe-OH |
Alanine, 3-phenyl- |
L-phenylalanine zwitterion |
S-phenylalanine |
(S)-(-)-Phenylalanine |
Thiohydrozimtsaeurephenylester |
(S)-a-Amino-b-phenylpropionic Acid |
Alanine, phenyl-, L- |
L-2-Amino-3-phenylpropionic acid |
(S)-2-Amino-3-phenylpropionic acid |
(S)-2-Amino-3-phenylpropanoic acid |
C6H5CH2CH(NH2)COOH |
(S)-a-Aminohydrocinnamic Acid |
Phenylalanine |
α-Aminohydrocinnamic acid, L- |
(L)-Phenylalanine |
Phenylalanine (VAN) |
Phenylalanine, L- |
Benzenepropanoic acid, α-amino-, (S)- |
l-Phe |
PhE |
phenyl 4-phenylthiobutanoate |
S-Phenyl-3-phenylpropanthioat |
β-phenyl-L-alanine |
(-)-Phenylalanine |
(S)-α-Aminobenzenepropanoic acid |
MFCD00064227 |
3-Phenylpropionyl-phenyl-thioether |
α-Amino-β-phenylpropionic acid |
3-Phenylthiopropionic acid,S-phenyl ester |
(S)-A-Aminobenzenepropanoic Acid |
Acetylcysteine Impurity 3 |