盐酸克立咪唑
盐酸克立咪唑结构式
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常用名 | 盐酸克立咪唑 | 英文名 | Clemizole hydrochloride |
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| CAS号 | 1163-36-6 | 分子量 | 362.296 | |
| 密度 | 1.25 g/cm3 | 沸点 | 506.1ºC at 760 mmHg | |
| 分子式 | C19H21Cl2N3 | 熔点 | 241 °C | |
| MSDS | 中文版 美版 | 闪点 | 259.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
Mol. Pharmacol. 86(5) , 514-21, (2014) Canonical transient receptor potential channel 5 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of transient receptor potential channels. It is predominantly found in the central nervous system with a high expressi... |
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Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Nat. Commun. 4 , 2410, (2013) Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures. One of its primary monogenic causes are mutations in Nav1.1 (SCN1A), a voltage-gated sodium channel. ... |
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Clemizole hydrochloride. Parvez M
Acta Crystallogr. C Struct. Chem. 52(4) , 904-905, (1996)
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